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Childhood steroid-sensitive nephrotic syndrome : characteristics and predictors of relapses : a study at a single center in Khartoum
المؤلفون المشاركون
al-Tajani, M. A. Ali
al-Hadi, Nahlah Muhammad
Abd al-Rahim, Muhammad B.
Ellidir, Rashid A.
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 13، العدد 3 (30 سبتمبر/أيلول 2018)، ص ص. 133-143، 11ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2018-09-30
دولة النشر
السودان
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background: Childhood steroid-sensitive nephrotic syndrome (SSNS) usually has a favorable outcome in spite of its relapsing course.
The objective of the authors was to study the demographic and clinical characteristics, outcome and risk factors for relapses in children with SSNS at a single center in Khartoum, Sudan.
Material and Methods: In this cross-sectional, facility-based study, the authors retrospectively reviewed all the records of children with SSNS, followed at the Pediatric Renal Unit, Soba University Hospital, Khartoum between 2001 and 2014.
SSRNS was defined as the remission of proteinuria within 4–6 weeks of corticosteroids.
Relapse is the recurrence of proteinuria after remission; frequent if ≥ 2 within initial six months or ≥ 4 within one year, and steroid dependence if 2 during therapy or within 14 days after stopping it.
Results: 330 children (males 220; 66.7%) with SSNS were studied with a mean age of 5.2 ± 3.5 years of whom 42.4% aged 1–5 years.
At the presentation, hypertension was detected in 31.8% and hematuria in 19.1%.
Serum cholesterol was elevated in all patients (mean 347.34 ± 117.87 mg/dl) and serum creatinine in 7.27% (mean 1.4 ± 0.35 mg/dl).
Renal histology showed mesangioproliferative glomerulonephritis (MesPGN) in 57.5%, minimal change disease (MCD) in 35.5%, and focal segmental glomerulosclerosis (FSGS) and IgM nephropathy in 3.5% each.
During the course of the illness, 10.3% achieved long-term remission, 89.7% relapsed— of whom 52.3% had frequent relapsing/steroid-dependent (FR/SD) course and 37.7% had infrequent relapses.
Risk of frequent relapses were age of onset and low/moderate socioeconomic status (P = 0.015 and 0.019, respectively).
Infections were recorded in 71.8%, but not significantly associated with the risk of frequent relapses (P > 0.05).
Conclusions: The majority children with SSNS at this single center in Khartoum had a relapsing course with the majority being FR or SD.
Predictors of frequent relapses were young age at onset and low socioeconomic status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Tajani, M. A. Ali& al-Hadi, Nahlah Muhammad& Abd al-Rahim, Muhammad B.& Ellidir, Rashid A.. 2018. Childhood steroid-sensitive nephrotic syndrome : characteristics and predictors of relapses : a study at a single center in Khartoum. Sudan Journal of Medical Sciences،Vol. 13, no. 3, pp.133-143.
https://search.emarefa.net/detail/BIM-835446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Tajani, M. A. Ali…[et al.]. Childhood steroid-sensitive nephrotic syndrome : characteristics and predictors of relapses : a study at a single center in Khartoum. Sudan Journal of Medical Sciences Vol. 13, no. 3 (2018), pp.133-143.
https://search.emarefa.net/detail/BIM-835446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Tajani, M. A. Ali& al-Hadi, Nahlah Muhammad& Abd al-Rahim, Muhammad B.& Ellidir, Rashid A.. Childhood steroid-sensitive nephrotic syndrome : characteristics and predictors of relapses : a study at a single center in Khartoum. Sudan Journal of Medical Sciences. 2018. Vol. 13, no. 3, pp.133-143.
https://search.emarefa.net/detail/BIM-835446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 140-143
رقم السجل
BIM-835446
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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