Antiparasitic effect of CdO NPS synthesized by simple chemical method SCM on leishmania donovani in vivo and in vitroherbicide glyphosate

المؤلفون المشاركون

Abd, Ahmad N.
Habubi, Nadir F.
Muhammad, Sabaa T.
Salman, Jihan Abd al-Sattar
Salman, Shaima D.
al-Marjani, Muhammad F.

المصدر

Mesopotamia Environment Journal

الناشر

جامعة بابل مركز البحوث و الدراسات البيئية

تاريخ النشر

2018-12-31

دولة النشر

العراق

عدد الصفحات

10

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)

الملخص الإنجليزي

In this study, the effect of cadmium oxide nanoparticles synthesized by a chemical method on Leishmania donovani In vitro and In vivo was evaluated.

In this study, (34-51) nm Cadmium Oxide Nanoparticles were prepared by Simple Chemical Method SCM .

The structural properties of the synthesized nanoparticles were investigated by using ransmission electron microscopy ,X-ray diffraction and UV-VIS spectrophotometer,.Viability percentage of promastigotes after adding CdO nanoparticles to the culture of parasite was estimated by MTT assay, then 18 mice were infected by 1×105 promastegotes/ml to study the effect of CdO nanoparticles on parasite in vivo.After 21days post inoculation all the mice were scarified, liver and intestine were removed for studying histopathological changes.

The treatment resulted in promastigote of Leishmania parasites with CdO nanoparticles 100% lead to highly decrease occurs in viability rate reached to( 80.92%;34.14%, and 7.51%) after (30min,1hr and 24hr) respectively.

The parasite viability rate treated with CdO nanoparticles (50%),which was (85.37%,46.48% and 8.21% ) respectively after same incubation period .Comparison with promastigote treated with pentostam showed significant decrease occur in parasite viability rate reached to (88.63%,78.37% and 63.08%) respectively, but less than CdO nanoparticles ,but untreated parasites which recorded only (95.87% ,94.12% and 88.82%) respectively ,there was significant (P<0.05) difference between all treatments.Conclusion: CdO NPs had antiparasitic effect on viability rate of Leishmania donovani in vivo and in vitro.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-835470

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