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Outcome of different treatment regimens used in newly diagnosed ITP pediatric patients
المؤلفون المشاركون
Harun, Mirfat al-Sayyid
Habib, Nisrin Mustafa
Afifi, Rasha Abd al-Rauf Abd al-Aziz
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 66، العدد 2 (30 يونيو/حزيران 2018)، ص ص. 39-42، 4ص.
الناشر
تاريخ النشر
2018-06-30
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Aim of the study: To compare the efficacy of different treatment options for newly diagnosed ITP in pediatrics.
Patients and methods: This is a retrospective observational study that reviewed data of 102 newly diagnosed ITP children.
Treatment regimens received by patients were classified into 5 types: Type I: pulse intravenous methylprednisolone followed by oral prednisolone then gradual tapering.
Type II: oral prednisolone 4 mg/kg/d 4 days.
Type III: oral prednisolone 2 mg/kg/d followed by gradual tapering.
Type IV: intravenous immune globulin (IVIG) combined with intravenous methylprednisolone.
Type V: no treatment.
Platelet counts at presentation, after 1 week, at 1 month, 3 months and 6 months from initial presentation were analyzed.
Results: Patients who received Type I, III or IV treatment showed statistically significant higher response to treatment at 1 week (96.1%, 93.3%, and 100% respectively) in comparison to those who received Type II or no treatment (Type V) in which less response was observed (58.8% and 75% respectively); (p-value = 0.
001%).
However, the overall response showed no statistically significant difference in response to treatment using different types of treatment at one month and 3 months, p-value = 0.086 and 0.335 respectively.
When we evaluated the response overtime of each line of treatment at 3 months, Type I showed a statistically significant response (p = 0.009) with the biggest number of patients continuing to maintain response up to 3 months.
Conclusion: We recommend the use of (methylprednisolone 20–30 mg/kg/d 3–5 days) followed by oral (prednisolone 2 mg/kg/d) due to rapid and sustained response
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harun, Mirfat al-Sayyid& Afifi, Rasha Abd al-Rauf Abd al-Aziz& Habib, Nisrin Mustafa. 2018. Outcome of different treatment regimens used in newly diagnosed ITP pediatric patients. Egyptian Pediatric Association Gazette،Vol. 66, no. 2, pp.39-42.
https://search.emarefa.net/detail/BIM-836026
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harun, Mirfat al-Sayyid…[et al.]. Outcome of different treatment regimens used in newly diagnosed ITP pediatric patients. Egyptian Pediatric Association Gazette Vol. 66, no. 2 (Jun. 2018), pp.39-42.
https://search.emarefa.net/detail/BIM-836026
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harun, Mirfat al-Sayyid& Afifi, Rasha Abd al-Rauf Abd al-Aziz& Habib, Nisrin Mustafa. Outcome of different treatment regimens used in newly diagnosed ITP pediatric patients. Egyptian Pediatric Association Gazette. 2018. Vol. 66, no. 2, pp.39-42.
https://search.emarefa.net/detail/BIM-836026
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 42
رقم السجل
BIM-836026
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