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Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer
المؤلفون المشاركون
Izz al-Din, Nada
Faruq, Hibah Allah
Qandil, Dina M.
Darwish, Amirah
al-Bastawisy, Ahmad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 179-183، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background: The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis.
Many types of cancers show reduced expression of FAS and elevated FasL expression.
The Fas21377G/A, and FasL2844T/C polymorphisms might be associated with increased risk of lung cancer.
Objective: The interplay between genetic polymorphisms could participate in cancer development.
This study aimed to examine the contribution of Fas21377AA and FasL2844CC genotypes to risk of developing lung cancer.
Subjects and methods: A case-control study was conducted on 20 non small cell lung cancer (NSCLC) cases and 40 controls.
Genotyping of Fas 21377AA and FasL 2844CC Single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were done to all subjects.
Results: The distribution of Fas and FasL genotypes showed a higher frequency of Fas AA genotype among patients compared to controls with an increased risk of lung cancer (OR 5.28; CI:1.35–20.65, P value .01).
No statistically significant difference was found between patients and controls groups in respect to FasL genotypes.
Gene to gene interaction between Fas and FasL genotypes showed significant differences between the patients and controls groups.
As regards the combination between FasL TT+CT & Fas AA, FasL CC & Fas GG+GA and FasL CC & Fas AA genotypes where patients carrying FasL CC or Fas AA genotypes have increased risk to develop lung cancer, (OR 10.28, 95% CI; 1.68–62.74, P value .01), (OR 72, 95% CI; 5.55– 132.99, P value .001) and (OR 9, 95% CI; 1.5–53.86, P value .01) respectively.
The FasL-CC genotype showed 2.25 folds increased risk to develop lung cancer in non-smoker patients, P = .008.
No correlation was found between the pathological types, the stage of lung cancer and the Fas and FasL genotypes.
Conclusion: The interaction of the cell death pathwaygenes Fas and FasL polymorphisms could be associated with the risk of lung cancer, in the same respect Fas AA genotype could also potentiate this risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Izz al-Din, Nada& Faruq, Hibah Allah& Qandil, Dina M.& Darwish, Amirah& al-Bastawisy, Ahmad. 2018. Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.179-183.
https://search.emarefa.net/detail/BIM-836323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Izz al-Din, Nada…[et al.]. Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.179-183.
https://search.emarefa.net/detail/BIM-836323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Izz al-Din, Nada& Faruq, Hibah Allah& Qandil, Dina M.& Darwish, Amirah& al-Bastawisy, Ahmad. Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.179-183.
https://search.emarefa.net/detail/BIM-836323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 183
رقم السجل
BIM-836323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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