Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration
المؤلفون المشاركون
Bakri, Norshakimah Md.
Ramachandran, Vasudevan
Kee, Hoo Fan
Subrayan, Visvaraja
Isa, Hazlita
Najah, Nur Fariza
Muhammad, Nur Afifah
Mooi, Ching Siew
Ismail, Patimah
Ismail, Fazliana
Sukiman, Erma Suryana
Sulayman, Wan Alya Wan
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 207-213، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Several studies in various populations have been conducted to determine candidate genes that could contribute to age-related macular degeneration (AMD) pathogenesis.
Objective: The present study was undertaken to determine the association of high temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF) and very-low-density receptor (VLDR) genes with wet AMD subjects in Malaysia.
Methods: A total of 125 subjects with wet AMD and 120 subjects without AMD from the Malaysian population were selected for this study.
Genomic DNA was extracted and copy number variations (CNVs) were determined using quantitative real-time Polymerase Chain Reaction (qPCR) and comparison between the two groups was done.
The demographic characteristics were also recorded.
Statistical analysis was carried out using software where a level of P < 0.05 was considered to be statistically significant.
Result: Statistically significant associations of the VEGF gene were observed in mean copy differences between case and control subjects (P < 0.05).
The consistency of both unadjusted and age-adjusted data at Copy Number CN gain (CN = 3 and CN = 4) suggested that VEGF could increase the risk of wet AMD disease (P < 0.05).
None of CNVs of HTRA1 and VLDR genes showed associations with the wet AMD disease based on comparisons of the frequencies of mean (P > 0.05).
Conclusion: Observations of an association between CNVs of VEGF gene and wet AMD have revealed that the CNVs of VEGF gene appears to be a possible contributor to wet AMD subjects in Malaysia-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakri, Norshakimah Md.& Ramachandran, Vasudevan& Kee, Hoo Fan& Subrayan, Visvaraja& Isa, Hazlita& Najah, Nur Fariza…[et al.]. 2018. Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.207-213.
https://search.emarefa.net/detail/BIM-836359
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakri, Norshakimah Md.…[et al.]. Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.207-213.
https://search.emarefa.net/detail/BIM-836359
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakri, Norshakimah Md.& Ramachandran, Vasudevan& Kee, Hoo Fan& Subrayan, Visvaraja& Isa, Hazlita& Najah, Nur Fariza…[et al.]. Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.207-213.
https://search.emarefa.net/detail/BIM-836359
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 213
رقم السجل
BIM-836359
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر