Synthesis, characterization, molecular docking and biological activity of 5,6-bis-(4-fluoro-phenyl)-3,4,7,8-tetraaza-bicyclo[8.3.1]tetradeca-1(13),4,6,10(14),11-pentaene-2,9-dione and its transition metal complexes
المؤلفون المشاركون
Jain, Preeti
Singh, Vandna
Ali, Sabir
Tripathi, Vishwas
Saraswat, Upendra
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 22، العدد 5 (31 يوليو/تموز 2018)، ص ص. 546-557، 12ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Macrocyclic Schiff base ligand through the condensation of 1,3-dicarbonyl-phenyl-dihy drazide with 4,40-difluorobenzil and its Co (II), Ni (II), Cu(II) and Zn (II) metal complexes have been synthesized.
The ligand and metal complexes were characterized by analytical and physicochemical methods.
An octahedral geometry arising from coordination of N2O2 donor atoms from the macrocyclic framework has been proposed for all metal complexes.
Synthesized ligand and metal complexes were investigated for in vitro antibacterial and antioxidant activity.
Complex [Ni(C22H14N4F2O2) (OCOCH3)2] has shown remarkable antibacterial activity (Minimum inhibitory concentration 8–16 lg / ml) comparable to commercial antibiotic Ciprofloxacin.
Anticancer activity of synthesized compounds against Squamous Cell Carcinoma (SCC4), head and neck cancer cell line has also been studied at different concentrations and at different time points.
Complexes [Co (C22H14N4F2O2) (NO3)2] and [Cu (C22H14N4F2O2) (OCOCH3)2] have shown remarkable anticancer results (IC50 31.1 and 43.1 lM) against the tested cell line in concentration dependent manner.
Molecular docking studies were carried out to find the binding mode of the synthesized macrocyclic Schiff base ligand to Epidermal Growth Factor Receptor (EGFR) Kinase (PDB ID : 1M17).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jain, Preeti& Singh, Vandna& Tripathi, Vishwas& Ali, Sabir& Saraswat, Upendra. 2018. Synthesis, characterization, molecular docking and biological activity of 5,6-bis-(4-fluoro-phenyl)-3,4,7,8-tetraaza-bicyclo[8.3.1]tetradeca-1(13),4,6,10(14),11-pentaene-2,9-dione and its transition metal complexes. Journal of Saudi Chemical Society،Vol. 22, no. 5, pp.546-557.
https://search.emarefa.net/detail/BIM-836366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jain, Preeti…[et al.]. Synthesis, characterization, molecular docking and biological activity of 5,6-bis-(4-fluoro-phenyl)-3,4,7,8-tetraaza-bicyclo[8.3.1]tetradeca-1(13),4,6,10(14),11-pentaene-2,9-dione and its transition metal complexes. Journal of Saudi Chemical Society Vol. 22, no. 5 (Jul. 2018), pp.546-557.
https://search.emarefa.net/detail/BIM-836366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jain, Preeti& Singh, Vandna& Tripathi, Vishwas& Ali, Sabir& Saraswat, Upendra. Synthesis, characterization, molecular docking and biological activity of 5,6-bis-(4-fluoro-phenyl)-3,4,7,8-tetraaza-bicyclo[8.3.1]tetradeca-1(13),4,6,10(14),11-pentaene-2,9-dione and its transition metal complexes. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 5, pp.546-557.
https://search.emarefa.net/detail/BIM-836366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 556
رقم السجل
BIM-836366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر