Association of interleukin-6 and its-174GC promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients
المؤلفون المشاركون
Hamid, Riham Muhammad Rafat
Muhammad, Sulayman Arif
Dwedar, Riham Ali
al-Khuli, Yasamin Sami
al-Jinjihi, Fatimah Talat
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 235-240، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: Interleukin-6 is a cytokine protein, which causes inflammation, maintains immune homeostasis and shows a role in rheumatoid arthritis pathogenesis.
IL-6-174G/C promoter polymorphism may have a role in susceptibility to RA.
Aim of the work: To evaluate the clinical significance of serum levels of IL-6 and its -174G/C promoter polymorphism in RA patients in comparison with the controls.
Patients and methods: This study enrolled 25 non hepatitis C virus RA patients versus 25 age and gender matched controls.
Demographic, clinical and laboratory data were prospectively evaluated.
Serum IL-6 level and promoter (-174G/C) genotype were determined.
Results: Serum IL-6 levels was significantly higher in RA patients compared to control subjects (p = .001), especially those with CC promoter polymorphism.
There was a significant correlation between IL and 6 level and duration of morning stiffness, disease activity, hemoglobin concentration and ESR level.
15/25 patients had (-174G/G) gene promoter polymorphism, 8/25 were GC and 2/25 were CC.
All controls were GG.
There was significant association between gene polymorphism and age at disease onset (p =.0172), which was older in those with GG genotype (38.5 ± 10.25 years) than those with CC (33.5 ± 0.71 years) and younger in GC genotypes (27.9 ± 7.9 years).
None of the other clinical, laboratory or radiological parameters would predict the IL-6 promoter polymorphism.
Conclusion: Serum IL-6 levels and -174G/C promoter polymorphism were higher in RA patients than in healthy controls.
The positive correlation of IL-6 level with the DAS28 and duration of morning stiffness may confirm its’ increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan.
The negative correlation of IL-6 level with the hemoglobin level may confirm IL-6 play a significant role in anemia of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hamid, Riham Muhammad Rafat& Muhammad, Sulayman Arif& Dwedar, Riham Ali& al-Khuli, Yasamin Sami& al-Jinjihi, Fatimah Talat. 2018. Association of interleukin-6 and its-174GC promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.235-240.
https://search.emarefa.net/detail/BIM-836506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hamid, Riham Muhammad Rafat…[et al.]. Association of interleukin-6 and its-174GC promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.235-240.
https://search.emarefa.net/detail/BIM-836506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hamid, Riham Muhammad Rafat& Muhammad, Sulayman Arif& Dwedar, Riham Ali& al-Khuli, Yasamin Sami& al-Jinjihi, Fatimah Talat. Association of interleukin-6 and its-174GC promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.235-240.
https://search.emarefa.net/detail/BIM-836506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 240
رقم السجل
BIM-836506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر