Association of nonalcoholic fatty liver disease grades with the plasma cell antigen-1 (PC-1) gene polymorphism
المؤلفون المشاركون
Burai, Ibrahim Hasan
Kamal, Maha Mustafa
Shakir, Yahya Muhammad
Izzat, Wafa M.
Ashur, Ismat
Afifi, Mayy
Jawdah, Wiam
al-Barashi, Maha M.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 241-246، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complicated disease linked with dietary habitats, obesity, and a range of comorbidities correlated with insulin resistance.
Although environmental parameters are essential in deciding risk of the disease, proofs from previous reports sustain the hypothesis that genetics are responsible for NAFLD developmentand progression.
Plasma cell antigen-1 (PC-1) and its gene polymorphism are associated with NAFLD progression.
Consequently, the object of this study was to detect the usefulness of PC-1 K121Q gene polymorphism in NAFLD progression.
Subjects and methods: A total of 87 NAFLD patients were included in the study and subdivided ultrasonographically into 31 patients with grade 1 (mild NAFLD), 26 patients with grade 2 (moderate NAFLD) and 30 patients with grade 3 (severe NAFLD), in addition to 47 normal controls.
The detection of PC-1 K121Q gene polymorphism was accomplished by using restriction fragment length polymorphism (RFLP)-PCR.
Results: Lipid profile parameters were associated with the incidence of NAFLD.
AlthoughPC-1 gene polymorphism didnot significantly change in parallel with NAFLD grades, PC-1 at the genetic and protein level was significantly associated with triacylglycerollevels in NAFLD patients.
Conclusion: Lipid profile indices are risk factors for the incidence of NAFLD.
Triacylglycerol (TAG) level is the hall-mark in the NAFLD pathogenesis and in the predisposition of PC-1 gene polymorphism
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burai, Ibrahim Hasan& Shakir, Yahya Muhammad& Kamal, Maha Mustafa& Izzat, Wafa M.& Ashur, Ismat& Afifi, Mayy…[et al.]. 2018. Association of nonalcoholic fatty liver disease grades with the plasma cell antigen-1 (PC-1) gene polymorphism. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.241-246.
https://search.emarefa.net/detail/BIM-836508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burai, Ibrahim Hasan…[et al.]. Association of nonalcoholic fatty liver disease grades with the plasma cell antigen-1 (PC-1) gene polymorphism. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.241-246.
https://search.emarefa.net/detail/BIM-836508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burai, Ibrahim Hasan& Shakir, Yahya Muhammad& Kamal, Maha Mustafa& Izzat, Wafa M.& Ashur, Ismat& Afifi, Mayy…[et al.]. Association of nonalcoholic fatty liver disease grades with the plasma cell antigen-1 (PC-1) gene polymorphism. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.241-246.
https://search.emarefa.net/detail/BIM-836508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 246
رقم السجل
BIM-836508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر