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No association between the SNP rs1625579 in miR-137 gene and schizophrenia in Iranian population
المؤلفون المشاركون
Abtahi, Azadeh
Samaei, Nadir Mansur
Gholipour, Naghmeh
Muradi, Nur al-Din
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 247-251، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background: Schizophrenia is a common and severe neuropsychiatric disorder with symptoms such as hallucination, delusion and mental disease.
Among candidate genes for schizophrenia, miR-137 gene has been recently suggested to contribute to schizophrenia by genome-wide association study (GWAS) and a single nucleotide polymorphism (SNP) rs1625579 (G>T) as a presumed risk allele within an intron of miR-137 gene has been contributed by schizophrenia.
Since mir-137 is a considerable gene in the performance of neural systems, the present study dealt with the association between SNP rs1625579 in miR-137 gene and schizophrenia in Iranian patients.
Aim of study: This study aimed to evaluate the association between SNP rs1625579 in miR-137 gene and schizophrenia in Iranian patients.
Methods: Hoping to identify a single-nucleotide polymorphism as a possible locus for schizophrenia, we carried out this case-control study on 80 blood samples collected from individuals suffering from schizophrenia and 48 healthy controls.
DNA was extracted from the samples, and the frequency of the polymorphisms was analyzed using ARMS-PCR method.
Finally, the products were detected on 1.5% agarose gel electrophoresis.
Results : The analysis on the data showed that 43.75% of the patients and 37.5% of the controls were mutant homozygous and 56.25% of the patients and 62.5% of controls were heterozygous.
In addition, 0.0% of the patients and 0.0% of the controls were normal homozygous.
Both the genotype (p = .48 > .05) and allele (p = .5 > .05) distribution of the rs1625579 SNP has no significant difference between patients and controls.
Conclusion: There was no significant relationship between rs1625579 and the incidence of schizophrenia.
To the best of our knowledge, this is first study in Iran that assesses the frequency of the polymorphism among Iranian patients.
However, further studies with more samples are necessary
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abtahi, Azadeh& Samaei, Nadir Mansur& Gholipour, Naghmeh& Muradi, Nur al-Din. 2018. No association between the SNP rs1625579 in miR-137 gene and schizophrenia in Iranian population. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.247-251.
https://search.emarefa.net/detail/BIM-836514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abtahi, Azadeh…[et al.]. No association between the SNP rs1625579 in miR-137 gene and schizophrenia in Iranian population. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.247-251.
https://search.emarefa.net/detail/BIM-836514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abtahi, Azadeh& Samaei, Nadir Mansur& Gholipour, Naghmeh& Muradi, Nur al-Din. No association between the SNP rs1625579 in miR-137 gene and schizophrenia in Iranian population. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.247-251.
https://search.emarefa.net/detail/BIM-836514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 250-251
رقم السجل
BIM-836514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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