The C-565T polymorphism (rs2422493) of the ATP-binding cassette transporter A1 gene contributes to the development and severity of coronary artery disease in an Iranian population
المؤلفون المشاركون
Soltanpour, Muhammad Sulayman
Mahmudi, Khalil
Ghaznavi, Habib
Kamali, Kurush
المصدر
العدد
المجلد 33، العدد 4 (31 يوليو/تموز 2018)، ص ص. 309-315، 7ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2018-07-31
دولة النشر
سلطنة عمان
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives: ATP-binding cassette transporter A1 (ABCA1) plays a pivotal role in reverse cholesterol transport from peripheral tissues back to the liver.
Abnormalities in ABCA1 function may lead to dyslipidemia and coronary artery disease (CAD).
We investigated the role of C-565T (rs2422493) promoter polymorphism of ABCA1 gene in the development and severity of CAD in an Iranian subpopulation.
Methods: Our study population consisted of 110 angiographically-confirmed CAD patients and 110 matched controls.
The severity of CAD was expressed based on the number of stenotic vessels.
Genotyping of C-565T promoter polymorphism was performed using the polymerase chain reaction followed by restriction fragments length polymorphism analysis methods.
Lipid profile was determined by routine colorimetric methods.
Results: The distribution of ABCA1 C-565T genotypes (p = 0.035) and alleles (p = 0.017) was significantly different between the CAD and control groups.
In univariate analysis (with genotype CC as reference), the TT genotype was significantly associated with an increased risk of CAD (odds ratio = 3.83; 95% confidence interval: 1.29–11.30, p = 0.014), but the CT genotype was not (p = 0.321).
A multiple binary logistic regression analysis revealed that smoking, hypertension, triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and ABCA1 C-565T dominant genotype were significant and independent risk factors for CAD development (p < 0.050).
The ABCA1 C-565T polymorphism affected the severity of CAD in TT homozygote state (p = 0.028).
However, no significant correlation was seen between this common polymorphism and lipid profile in the study population (p > 0.050).
Conclusions: Our study indicated that ABCA1 C-565T polymorphism is a significant risk factor for development and severity of CAD in our population
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmudi, Khalil& Kamali, Kurush& Ghaznavi, Habib& Soltanpour, Muhammad Sulayman. 2018. The C-565T polymorphism (rs2422493) of the ATP-binding cassette transporter A1 gene contributes to the development and severity of coronary artery disease in an Iranian population. Oman Medical Journal،Vol. 33, no. 4, pp.309-315.
https://search.emarefa.net/detail/BIM-838234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghaznavi, Habib…[et al.]. The C-565T polymorphism (rs2422493) of the ATP-binding cassette transporter A1 gene contributes to the development and severity of coronary artery disease in an Iranian population. Oman Medical Journal Vol. 33, no. 4 (Jul. 2018), pp.309-315.
https://search.emarefa.net/detail/BIM-838234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmudi, Khalil& Kamali, Kurush& Ghaznavi, Habib& Soltanpour, Muhammad Sulayman. The C-565T polymorphism (rs2422493) of the ATP-binding cassette transporter A1 gene contributes to the development and severity of coronary artery disease in an Iranian population. Oman Medical Journal. 2018. Vol. 33, no. 4, pp.309-315.
https://search.emarefa.net/detail/BIM-838234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 314-315
رقم السجل
BIM-838234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر