MicroRNA-4728 serves as a suppressor and antagonist of oncogenic MAPK in burkitt lymphoma

الملخص EN

Objective: This study identified the biological role of miR-4728 in Burkitt lymphoma (BL) process.

Methods: Ramos cells were used to analyze MicroRNA-4728 (miR-4728) biological functions.

MiR-4728 expression was investigated in 14 randomly chosen tumor tissues and 12 noncancerous tissues by qRTPCR.

Cyquant assay was used to monitor cell proliferation.

Colony formation assay was performed to study the effectiveness of miR-4728 on the proliferation of cells.

The effects of miR-4728 on MAPK signaling pathway were detected by luciferase reporter assay.

The significance of differences between groups were evaluated by SPSS.

Results: In this study, MiRNA-4728 was observed to down-regulated in BL tissues compared to the noncancerous tissues.

Additionally, miR-4728 inhibited Ramos cell proliferation.

Moreover, miR-4728 overexpression also decreased the MAPK signaling activity.

Conclusion: Our results suggested that miR-4728 serves as a suppressor and antagonist of oncogenic MAPK in Burkitt lymphoma.

The appropriate regulation of miR-4728 might be vital to improve BL treatment.