MicroRNA-4728 mediated regulation of MAPK oncogenic signaling in papillary thyroid carcinoma

الملخص EN

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer that accounts for 85% of thyroid cancers.

MicroRNAs (miRNAs) have been reported to play important roles in the biological processes in cancer.

In this study, we analyzed the biological role of miR-4728 in human PTC process in human PTC cell lines in vitro.

MiRNA-4728 was observed to down-regulated in human PTC tissues and PTC cell lines.

Additionally, miR-4728 inhibited PTC cell proliferation.

Further study demonstrated SOS1 was repressed by miR-4728 and overexpression of miR-4728 down-regulated both the mRNA and protein levels of SOS1.

Moreover, miR-4728 overexpression also decreased the MAPK signaling activity.

These observations suggested that miR-4728 could inhibit the process of human PTC through regulating MAPK signaling pathway.

And, appropriate regulation of miR-4728 might be vital to improve human PTC treatment