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Early-life gut microbiome and cow’s milk allergy : a prospective case control 6-month follow-up study
المؤلفون المشاركون
Feng, Jing-jing
Yan, Dong-yong
Lyu, Yu-jing
Xu, Xiu
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 5 (31 يوليو/تموز 2018)، ص ص. 875-880، 6ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Increasing evidence suggests that perturbations in the intestinal microbiota in early infancy are implicated in the pathogenesis of food allergy (FA); existing evidence on the structure and composition of the intestinal microbiota in human beings with FA is limited and conflicting.
The main object of the study was to compare the faecal microbiota between healthy and cow’s milk allergy (CMA) infants at the baseline immediately after the diagnosis, and to evaluate the changes in the faecal microbiota after 6 months of treatment of CMA infants with hypoallergenic formula (HF), compared with healthy children fed on standard milk formulae.
Sixty infants younger than 4 months of age with challenge-proven CMA and 60 healthy age-matched children were investigated in this prospective case - control follow-up study.
Faecal samples were collected at baseline and at 6 months of follow-up, microbial diversity and composition were characterized by high-throughput 16S rRNA sequencing.
The average age (±SD) of the infants at inclusion was 2.9 ± 1.0 months.
Children with CMA have lower gut microbiota diversity and an elevated Enterobacteriaceae to Bacteroidaceae (E/B ratio) in early infancy compared with healthy children (115.8 vs.
0.8, P = 0.0002).
After 6 months of treatment with HF, CMA infants had a higher Lactobacillaceae (6.3% vs.
0.5%, P = 0.04) and lower Bifidobacteriaceae (0.3% vs.
8.2%, P = 0.03) and Ruminococcaceae (1.5% vs.
10.5%, P = 0.03) abundance compared with control children.
Conclusion: Low gut microbiota diversity and an elevated E/B ratio in early infancy may contribute to the development of FA, including CMA.
A strict elimination diet may weaken FA by reducing E/B ratio and promoting a gut microbiota that would benefit the acquisition of oral tolerance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Ping& Feng, Jing-jing& Yan, Dong-yong& Lyu, Yu-jing& Xu, Xiu. 2018. Early-life gut microbiome and cow’s milk allergy : a prospective case control 6-month follow-up study. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.875-880.
https://search.emarefa.net/detail/BIM-838477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Jing-jing…[et al.]. Early-life gut microbiome and cow’s milk allergy : a prospective case control 6-month follow-up study. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.875-880.
https://search.emarefa.net/detail/BIM-838477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Ping& Feng, Jing-jing& Yan, Dong-yong& Lyu, Yu-jing& Xu, Xiu. Early-life gut microbiome and cow’s milk allergy : a prospective case control 6-month follow-up study. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.875-880.
https://search.emarefa.net/detail/BIM-838477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 879-880
رقم السجل
BIM-838477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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