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Synthesis, anti-bacterial and anti-cancer activities of some antipyrine diazenyl benzaldehyde derivatives and antipyrine-based heterocycles
المؤلفون المشاركون
Hassan, Huda A.
Hassan, Dhifaf F.
al-Rawi, Muna Samir Said
المصدر
Iraqi National Journal of Chemistry
العدد
المجلد 17، العدد 2 (30 يونيو/حزيران 2017)، ص ص. 140-148، 9ص.
الناشر
تاريخ النشر
2017-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present study envisaged utilizing 4-aminoantipyrine as key intermediate for the synthesis of some new derivatives bearing anti-bacterial and anti-cancer activities moieties viz., antipyrine diazenyl benzaldehydes 2(a-d) which were obtained by coupling of diazotized 4-aminoantipyrine (1) with substituted benzaldehydes at 0◦C (iced) temperature.
The other antipyrine derivatives where containing bis heterocycles like bis thiazolidinone-antipyrine (4), bis imidazolidinone -antipyrine (5) and bis azetidinone -antipyrine (6).These compounds were prepared through the reaction between 4-aminoantipyrine and terephthaldicarboxaldehyde to get (3) which were reacted with mercaptoacetic acid , glycine or chloroacetyl chloride separately to get compounds (4), (5) and (6) respectively.
The structures of all compounds were stablished on bases of melting points, FTIR, 1HNMR , mass spectroscopy (for some compound) and elemental analysis.
These derivatives were investigated for their anti-bacterial activity against two kinds of bacteria(G-) and (G+) and compared to the Amoxicilin and Lincomycin standard drugs.
Two cancer cell lines include: The human pelvic rhabdomyosarcoma (RD) and the mouse cell line( L20B) were used in this study and these derivatives showed different cytotoxic activity in vitro.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rawi, Muna Samir Said& Hassan, Huda A.& Hassan, Dhifaf F.. 2017. Synthesis, anti-bacterial and anti-cancer activities of some antipyrine diazenyl benzaldehyde derivatives and antipyrine-based heterocycles. Iraqi National Journal of Chemistry،Vol. 17, no. 2, pp.140-148.
https://search.emarefa.net/detail/BIM-838670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rawi, Muna Samir Said…[et al.]. Synthesis, anti-bacterial and anti-cancer activities of some antipyrine diazenyl benzaldehyde derivatives and antipyrine-based heterocycles. Iraqi National Journal of Chemistry Vol. 17, no. 2 (2017), pp.140-148.
https://search.emarefa.net/detail/BIM-838670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rawi, Muna Samir Said& Hassan, Huda A.& Hassan, Dhifaf F.. Synthesis, anti-bacterial and anti-cancer activities of some antipyrine diazenyl benzaldehyde derivatives and antipyrine-based heterocycles. Iraqi National Journal of Chemistry. 2017. Vol. 17, no. 2, pp.140-148.
https://search.emarefa.net/detail/BIM-838670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 147-148
رقم السجل
BIM-838670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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