Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 4 (31 مايو/أيار 2018)، ص ص. 747-754، 8ص.
الناشر
تاريخ النشر
2018-05-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Liver fibrosis is a major health concern that results in significant morbidity and mortality.
Up-to-date, there is no standard treatment for fibrosis because of its complex pathogenesis.
Crocin is one of the main nutraceuticals isolated from the stigma of Crocus sativus with antioxidant and anti-inflammatory activities.
The current study aimed at evaluating the potential antifibrotic activity of crocin against thioacetamide (TAA)-induced liver fibrosis in mice as well as the underlying mechanism using silymarin as a reference antifibrotic product.
Crocin at two doses (25 and 100 mg/kg) significantly ameliorated the rise in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and total bilirubin (TB).
Further, the high dose significantly protected against the increase in serum total cholesterol (TC) and triglycerides (TG).
These effects were confirmed by light microscopic examinations.
Crocin antioxidant activities were confirmed by the observed inhibition of reduced glutathione depletion (GSH), super oxide dismutase (SOD) exhaustion and malondialdehyde (MDA) accumulation in liver tissue.
The antifibrotic effects of crocin were explored by assessing fibrosis related gene expression.
Administration of crocin (100 mg/kg) hampered expression of tumor growth factor-b (TGF-b), a alpha smooth muscle actin (a-SMA) and collagen 1-a expression and significantly raised gene expression of matrix metalloproteinase-2 (MMP-2).
Further, it reduced protein expression of nuclear factor-jB (NF-jB) and cyclooxygenase-2 (COX-2) as assessed immunohistochemically.
These antiinflammatory effects were confirmed by the observed protein expression of interleukin-1b (IL-1b) and tumor necrosis factor-a (TNF-a).
Thus, it can be concluded that crocin protects against TAA-induced liver fibrosis in mice.
This can be ascribed, at least partly, to its antioxidant and anti-inflammatory effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jandabi, Mardi Muhammad. 2018. Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice. Saudi Journal of Biological Sciences،Vol. 25, no. 4, pp.747-754.
https://search.emarefa.net/detail/BIM-838807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Jandabi, Mardi Muhammad. Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice. Saudi Journal of Biological Sciences Vol. 25, no. 4 (May. 2018), pp.747-754.
https://search.emarefa.net/detail/BIM-838807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jandabi, Mardi Muhammad. Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 4, pp.747-754.
https://search.emarefa.net/detail/BIM-838807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 753-754
رقم السجل
BIM-838807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر