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Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea
المؤلفون المشاركون
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 4 (31 مايو/أيار 2018)، ص ص. 832-837، 6ص.
الناشر
تاريخ النشر
2018-05-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Present investigation evaluates the effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea.
Briefly, electron spine resonance was used for the estimation of radical scavenging activity of daidzin and COX Fluorescent Activity Assay Kit was used for the estimation of PGS activity.
Dry eye rat model was developed by removing the lacrimal gland and effect of daidzin was evaluated in dry eye rat model by estimating the fluorescein score, tear volume and expressions of heme oxigenase (HO-1), TNF a, Interlukin 6 (IL-6), matrix metallopeptidase 9 (MMP-9) and PGS-2.
Result of the present study suggested that daidzin possess tyrosyl radical scavenging activity and thereby decreases the oxidative stress.
Activity of PGS significantly increases in dry eye which was inhibited by daidzin treatment due to competitive inhibition of PGS.
It also recovers the tear volume in dry eye rat model in which lacrimal gland was removed.
Thus corneal erosion was improved by daidzin in dry eye rat model.
Thus present study concludes that treatment with daidzin protects the cornea in dry eye rat model by suppression inflammation and oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiao, Fan& Cui, Hua& Zhong, Xiao. 2018. Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Saudi Journal of Biological Sciences،Vol. 25, no. 4, pp.832-837.
https://search.emarefa.net/detail/BIM-838860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiao, Fan…[et al.]. Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Saudi Journal of Biological Sciences Vol. 25, no. 4 (May. 2018), pp.832-837.
https://search.emarefa.net/detail/BIM-838860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiao, Fan& Cui, Hua& Zhong, Xiao. Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 4, pp.832-837.
https://search.emarefa.net/detail/BIM-838860
نوع البيانات
مقالات
لغة النص
الإنجليزية
رقم السجل
BIM-838860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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