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Combined use of vitamins E and C improve nephrotoxicity induced by colistin in rats
المؤلفون المشاركون
Ghlissi, Zahrah
Zaghal, Khalid
Boudawara, Tahiya
Rabbai, Tariq
Sahnun, Zuhayr
Hakim, Ahmad
Mnif, Hela
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 3 (30 يونيو/حزيران 2018)، ص ص. 545-553، 9ص.
الناشر
تاريخ النشر
2018-06-30
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study was performed to investigate the protective effect of combined use of Vitamins E and C on colistin-induced tubular damage in rat.
Animals were treated with sterile saline, colistin methanesulfonate (CMS), CMS + Vitamin E + Vitamin C, and Vitamin E + vitamin C, respectively, for seven days.
Thereafter, animals were sacrificed and the urine N-acetyl-b-Dglucosaminidase (NAG) and gamma-glutamyl transferase (GGT) levels, plasma level of creatinine (Cr), vitamin E and vitamin C, and renal tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as renal histology were performed.
CMS induced acute tubular necrosis, increased the NAG, GGT, and MDA levels, and reduced the Vitamin E, Vitamin C, SOD, CAT, and GPx activities.
Cotreatment with vitamins E and C restored all biochemical parameters cited above and improved the histopathological damage.
Tubular damage induced by colistin is at least partly due to oxidative stress.
Nephroprotective effect of Vitamins E and C is partially mediated through its antioxidant properties, and the higher protection by the combination of these vitamins is related to its synergistic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghlissi, Zahrah& Hakim, Ahmad& Mnif, Hela& Zaghal, Khalid& Rabbai, Tariq& Boudawara, Tahiya…[et al.]. 2018. Combined use of vitamins E and C improve nephrotoxicity induced by colistin in rats. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 3, pp.545-553.
https://search.emarefa.net/detail/BIM-839160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghlissi, Zahrah…[et al.]. Combined use of vitamins E and C improve nephrotoxicity induced by colistin in rats. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 3 (Jun. 2018), pp.545-553.
https://search.emarefa.net/detail/BIM-839160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghlissi, Zahrah& Hakim, Ahmad& Mnif, Hela& Zaghal, Khalid& Rabbai, Tariq& Boudawara, Tahiya…[et al.]. Combined use of vitamins E and C improve nephrotoxicity induced by colistin in rats. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 3, pp.545-553.
https://search.emarefa.net/detail/BIM-839160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 552-553
رقم السجل
BIM-839160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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