Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole
المؤلفون المشاركون
Abd al-Latif, Amal Muhammad
al-Khatib, Suha Samir Hasan
al-Shal, Amal Said
Yusuf, Dua Muhammad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 3 (30 يونيو/حزيران 2018)، ص ص. 591-597، 7ص.
الناشر
تاريخ النشر
2018-06-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Levamisole is often discussed as the first alternative to steroids.
It is an antihelminthic drug that has been used for steroid-sensitive nephrotic syndrome (SSNS) for more than 20 years.
Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses.
The aim of the study was to investigate the IL-18 levels in serum from children with SSNS during relapse and remission after using levamisole or three months in a trial to test the efficacy of its action in reducing frequency of relapses in SSNS.
This study was done on 23 children with frequently relapsing SSNS treated with levamisole besides steroids, then followed up three months; 16 males and seven females (mean age: 7.96 years and median 8 years).
Clinical and laboratory assessments were done before starting therapy and after three months including cumulative dose of steroids and serum IL-18.
We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of steroids.
Levamisole effectiveness in reduction of relapses of SSNS may be due to resetting of the type 1/type 2 imbalance, proved by induction of IL 18 may be useful in the therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yusuf, Dua Muhammad& Abd al-Latif, Amal Muhammad& al-Khatib, Suha Samir Hasan& al-Shal, Amal Said. 2018. Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 3, pp.591-597.
https://search.emarefa.net/detail/BIM-839171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yusuf, Dua Muhammad…[et al.]. Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 3 (Jun. 2018), pp.591-597.
https://search.emarefa.net/detail/BIM-839171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yusuf, Dua Muhammad& Abd al-Latif, Amal Muhammad& al-Khatib, Suha Samir Hasan& al-Shal, Amal Said. Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 3, pp.591-597.
https://search.emarefa.net/detail/BIM-839171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 597
رقم السجل
BIM-839171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر