Histopathological study of r-fsh effects on female reproductive system, liver and kidneys in rattus norvegicus rats
العناوين الأخرى
دراسة مرضية نسيجية حول تأثير الهرمون المحفز للحويصلات على الجهاز التناسلي و الكبد و الكلى لإناث الجرذان
المؤلفون المشاركون
Ghalib, Nurah Saghir
Hamzah, Batul Salim
Abd al-Karim, Qasim Fawzi
المصدر
Basrah Journal of Veterinary Research
العدد
المجلد 16، العدد 2 (31 ديسمبر/كانون الأول 2017)، ص ص. 334-343، 10ص.
الناشر
جامعة البصرة كلية الطب البيطري
تاريخ النشر
2017-12-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study aims to evaluate the histopathological changes induced by recombinant follicle stimulating hormone (follitropin alpha) on reproductive organs as well as the liver and kidneys of female rats.
The experiment was done on 24 white female rats (Rattus norvegicus) sexually mature weighing 150-200 gram, divided into 4 equal groups of 6 animals: control group which was given distilled water.
Single dose group, double dose group and triple dose groups which were injected by 0.5 iu.,1 iu.
and 1.5 iu of recombinant FSH respectively.
The drug was given subcutaneously during the pro-estrous phase for ten consecutive cycles, then animals from each group were sacrificed to study the histopathological changes.
The histopathological examination of the ovaries, uterus, liver, and kidneys revealed variable changes in different organs.The ovarian sections showed many Graafian follicles without ova and many corpus luteal cysts, fibrosis, and thickened granulosa cell layer, and the ovary was surrounded by excessive adipose tissue.
The uterus in single and double doses showed dilated cavity, thin endometrium, thin muscular layer and diminished endometrial glands while in triple dose showed atrophy of endometrial lining and glands, hypertrophied muscular layer with slit like endometrial cavity and formation of multiple endometrial cyst.
The liver sections showed few changes like dilated central vein, congestion of sinusoids, vacuolation of hepatocytes, with moderate degree of fatty degeneration A few hepatocytes appeared necrotic but without inflammatory response.
The kidneys in single and double doses showed unremarkable changes, while in triple dose glomerular congestion, congested vessels, hemorrhage, and degeneration and necrosis of proximal tubules were found.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghalib, Nurah Saghir& Hamzah, Batul Salim& Abd al-Karim, Qasim Fawzi. 2017. Histopathological study of r-fsh effects on female reproductive system, liver and kidneys in rattus norvegicus rats. Basrah Journal of Veterinary Research،Vol. 16, no. 2, pp.334-343.
https://search.emarefa.net/detail/BIM-840152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghalib, Nurah Saghir…[et al.]. Histopathological study of r-fsh effects on female reproductive system, liver and kidneys in rattus norvegicus rats. Basrah Journal of Veterinary Research Vol. 16, no. 2 (2017), pp.334-343.
https://search.emarefa.net/detail/BIM-840152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghalib, Nurah Saghir& Hamzah, Batul Salim& Abd al-Karim, Qasim Fawzi. Histopathological study of r-fsh effects on female reproductive system, liver and kidneys in rattus norvegicus rats. Basrah Journal of Veterinary Research. 2017. Vol. 16, no. 2, pp.334-343.
https://search.emarefa.net/detail/BIM-840152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 342-343
رقم السجل
BIM-840152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر