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The effect of aerobic training on tumor growth, adiponectin, leptin and ghrelin in mice with breast cancer
المؤلفون المشاركون
Kazimi, Abd al-Rida
Shalamzari, Sadegh Amani
Daneshfar, Amin
Sablouei, Mozhgan Hasanzadeh
Singh, Maria A. Fiatarone
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 20، العدد 2 (28 فبراير/شباط 2018)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2018-02-28
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: Breast cancer is widespread in Iran and exercise training is an adjuvant strategy for managing this illness.
Objectives: The aim of this study was to investigate the effects of aerobic training on tumor growth and its relationship with changes in adiponectin, leptin, and ghrelin in mice with breast cancer.
Materials and Methods: In this animal experimental study, which was conducted during year 2016 in Iran, 20 female BALB/c mice were randomly divided to two groups: Tumor Control (TC) and Exercise (E).
The MC4L2 cancer cells were injected in the mice.
The E group then performed progressive aerobic training for six weeks.
Tumor volume, food intake, weight, and muscle endurance of all mice were measured weekly.
At six weeks, the mice were sacrificed and tumor, gastrocnemius muscle, and heart weights were measured.
Level of cytokines/hormones were quantified using the Enzyme Linked Immunosorbent Assay (ELISA) methodology in tumor, serum, muscle, and adipose tissue.
Results: Aerobic exercise training was associated with a significantly decreased growth rateandfinal weight of thetumor(1.11 versus 2.74 g) compared to the TC group (P < 0.05).
Exercising mice also had greater food intake, muscle endurance, heart weight (0.12 versus 0.09 g), and muscle weight (0.078 versus 0.045 mg) when compared with the TC group (P < 0.05).
In addition, the E group had significantly increased adiponectin in all sites except the tumor, decreased leptin in all sites, and increased ghrelin in serum compared to the TC group (P < 0.05).
Conclusions: Aerobic exercise training in mice with breast cancer attenuated tumor burden and cachexia, and improved appetite, muscle size and function and fitness relative to non-exercising controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shalamzari, Sadegh Amani& Daneshfar, Amin& Sablouei, Mozhgan Hasanzadeh& Singh, Maria A. Fiatarone& Kazimi, Abd al-Rida. 2018. The effect of aerobic training on tumor growth, adiponectin, leptin and ghrelin in mice with breast cancer. Iranian Red Crescent Medical Journal،Vol. 20, no. 2, pp.1-9.
https://search.emarefa.net/detail/BIM-840380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shalamzari, Sadegh Amani…[et al.]. The effect of aerobic training on tumor growth, adiponectin, leptin and ghrelin in mice with breast cancer. Iranian Red Crescent Medical Journal Vol. 20, no. 2 (Feb. 2018), pp.1-9.
https://search.emarefa.net/detail/BIM-840380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shalamzari, Sadegh Amani& Daneshfar, Amin& Sablouei, Mozhgan Hasanzadeh& Singh, Maria A. Fiatarone& Kazimi, Abd al-Rida. The effect of aerobic training on tumor growth, adiponectin, leptin and ghrelin in mice with breast cancer. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 2, pp.1-9.
https://search.emarefa.net/detail/BIM-840380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-840380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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