Overdoseof tussirum induced histopathological changes of the liver and kidney in male domastic rabbits

الملخص EN

In this study, the histopathological changes due to overdose usage of Tussirum drug(0.75 and 3 ml/Kg)in liver and kidney were assessed in rabbite with light microscopes.

Six male rabbites(1 ± 0.5 Kg ) were included and divided into three groups.Normal saline (3ml/Kg) wasgiven orally as placebo in the control groupI (N= 2).

Group II and III(N= 4 for each) was received Tussirum orallyat a single dose of (0.75 and 3ml/kg/day) for 30 days respectively.

the results were recorded that both doses of Tossirum were induced that blood vessel congestion, aggregation of Kuppfer cells,inflamintion infiltrations and Sinusoidal dilatation in the liver parenchyma in addition to the cytoplasmic vacuolation, degeneration, pyknotic nuclei in the hepatocytes and.

On the other hand, renal damage was observed in the kidneys of treated rabbits, necrosis of glomular, degeneration of nucli and degeneration in the lining epithelial cells of renal, also noted that glomular shrinkage, dilated of reanal tubules and hyperplasia of tubles walls,as well as to necrosis of renal tubules endothelium, closing of renal tubules lumen, isulation of renal tubules endothelium and density in some nucli chromatic Finally, the investigators concluded that Tossirum toxicity induced hepatocellular and renal damage.