Clinical evaluation of intravenous dexmedetomidine and intravenous midazolam for hysterectomy under subarachnoid blockade with 0.5 % hyperbaric bupivacaine
المؤلفون المشاركون
Gupta, Kumkum
Bansal, Manoranjan
Gupta, Prashant K.
Rastogi, Bhawana
Singh, Ivesh
Tyag, Vasundhera
المصدر
Ain Shams Journal of Anesthesiology
العدد
المجلد 10، العدد 1 (31 مارس/آذار 2017)، ص ص. 279-286، 8ص.
الناشر
جامعة عين شمس كلية الطب قسم التخدير
تاريخ النشر
2017-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background The excellence of subarachnoid blockade (SAB) can be improved with a variety of adjuvants, used either intrathecally or intravenously.
Objective The present study aimed to compare the clinical efficacy of intravenous dexmedetomidine with midazolam for hysterectomy under SAB with 0.5% hyperbaric bupivacaine.
Materials and methods After approval, 90 adult consenting middle-aged female patients of American Society of Anesthesiologists (ASA) physical status I and II scheduled for hysterectomy under SAB were blindly randomized into three groups of 30 patients each, to receive either intravenous dexmedetomidine 0.5 μg/kg (group I) or intravenous midazolam 0.05 mg/kg (group II) or normal saline (group III), 20 min after the SAB.
Patients were assessed for the onset and duration of sensory and motor blockade, maximum cephalic spread, and intraoperative hemodynamic changes as primary endpoints.
The study also evaluated the sedation level and visual analogue scale score for postoperative pain as secondary outcome.
Results Patients in the dexmedetomidine group showed a higher cephalic level of sensory blockade.
Time for two dermatomes’ sensory regression (144.33±19.2 min) and duration of sensory analgesia (270.10±16.6 min) in the dexmedetomidine group was extended, with a statistically highly significant difference among the groups and no hemodynamic variability.
Ramsay sedation score was higher in the dexmedetomidine and midazolam groups than in the saline group.
Respiratory depression was not observed in any patient.
The incidence of postspinal shivering was low in patients of the dexmedetomidine group.
Conclusion Midazolam provided only sedation, whereas dexmedetomidine extended the duration of sensory analgesia of SAB, maintained hemodynamic stability, and also provided arousable sedation without respiratory depression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gupta, Kumkum& Rastogi, Bhawana& Gupta, Prashant K.& Singh, Ivesh& Bansal, Manoranjan& Tyag, Vasundhera. 2017. Clinical evaluation of intravenous dexmedetomidine and intravenous midazolam for hysterectomy under subarachnoid blockade with 0.5 % hyperbaric bupivacaine. Ain Shams Journal of Anesthesiology،Vol. 10, no. 1, pp.279-286.
https://search.emarefa.net/detail/BIM-841397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gupta, Kumkum…[et al.]. Clinical evaluation of intravenous dexmedetomidine and intravenous midazolam for hysterectomy under subarachnoid blockade with 0.5 % hyperbaric bupivacaine. Ain Shams Journal of Anesthesiology Vol. 10, no. 1 (Mar. 2017), pp.279-286.
https://search.emarefa.net/detail/BIM-841397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gupta, Kumkum& Rastogi, Bhawana& Gupta, Prashant K.& Singh, Ivesh& Bansal, Manoranjan& Tyag, Vasundhera. Clinical evaluation of intravenous dexmedetomidine and intravenous midazolam for hysterectomy under subarachnoid blockade with 0.5 % hyperbaric bupivacaine. Ain Shams Journal of Anesthesiology. 2017. Vol. 10, no. 1, pp.279-286.
https://search.emarefa.net/detail/BIM-841397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 286
رقم السجل
BIM-841397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر