Alpha human atrial natriuretic peptide in mitral valve diseases with and without atrial fibrillation

الملخص EN

In our study we have measured the levels of a h ANP in blood from the right, ventricle by radioimmunoassay in patients with mitral valve disease (MVD) whether associated with atrial fibrillation (AF) (15 patients) or with sinus rhythm (16 patients).

The group of patients was also classified according to the nature of the valve lesion into patients with isolated mitral stenosis (MS) (10 patients), patients with mitral regurge (MR) (8 patients), and patients with combined MS and MR (13 patients).

A third classification of the group of patients according to the presence or absence of tricusped regurge (TR) into the group of patients with MVD associated with TR (10 patients) and.

MV1) not associated with TR (21 patients).

The control group in our study was formed of 15 patients with aortic valve disease and good left ventricular function.

The concentration of a h ANP were found to be highly significantly elevated (P < 0.001) in the group of patients with MVD and AF (m 246.09 + 394.92 pgm /ml), the group of patients with combined M.S.

and MR (m 423.0 ± 665 + 28 pgm / ml), and the group of patients with MVD and TR (m 714.76 ± 726.14 pgm /ml) than the control group On 24.62±15.9 pgm /ml).

a h ANP concentrations were also found lo be significantly elevated (P<0.05) in She group of patients with MVD and sinus rhythm (m 402.21619 25 pgm / ml), the group of patients with MVD not associated with TR On i:i8.

i5 ± 24J 72 pgm/ml) than the control group.

However no statistically significant difference in the levels of ANP could be found between the grout) of patients with MS (in 121.8(0279.79 pgm hnl) and the control group, nor between the group of patients with MVD and sinus rhythm and the group of patients with MVD and AF.

On the other hand, the levels of a h ANP were found to be significantly elevated in group of patients with MR and patients with MS and MR than the group of patients with MS.

As regard the correlation studies, a h ANP was found lo have a significant positive correlation with pulmonary capillary wedge pressure, right atrial pressure, pulmonary artery pressure and right ventricular pressure in some of our groups of patients.

A significant, negative correlation wax found between a h ANP levels and left venture.

alar systolic pressure and aortic pressures in the group of patients with MH.

No significant correlation could be found between a h ANP concentrations and left atrial diameter and heart rate in any of our groups of patients.

From these results we can conclude that a h ANP is elevated in cases of MVD whether associated with AF or sinus rhythm and whether associated, with.

TR or not.