Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-a NF-jB pathway induced inflammation and matrix metalloproteinase-2 9 expression in rat cerebral ischemia
المؤلفون المشاركون
Chen, Xiao Juan
Zhang, Jian Guo
Wu, Lan
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 6 (30 سبتمبر/أيلول 2018)، ص ص. 1033-1039، 7ص.
الناشر
تاريخ النشر
2018-09-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cerebral ischemic damage and infarction are well documented in stroke, which is presenting a foremost health concern globally with very high mortality and morbidity rates.
Mechanisms that are associated with excitotoxicity, inflammation and oxidative stress are found to be critically involved in ischemic damage.
Adverse effects of current therapies are imposing the need in development of neuroprotective agents that are very effective.
To explore this we experimentally induced ischemic brain injury and investigated the effects of plumbagin.
Induction of cerebral infarction and ischemia-reperfusion (I/R) was done by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats.
Plumbagin (50, 100 or 200 mg/kg b.
wt) was intragastrically administered for 9 days before ischemia induction and an hour prior on the day of ischemic insult.
Plumbagin treatment attenuated pulmonary edema, neuronal apoptosis and reduced cerebral infarct volume.
Cleaved caspase-3 and apoptotic cascade protein expressions were regulated.
Overproduction of pro-inflammatory cytokines (TNF-a, IL-1b and IL-6) and nitric oxide (NO) following I/R were reduced.
Prior plumbagin administration had down-regulated NF-jB signalling and MMP-2 and MMP-9 expression.
Overall, the results reveal the potent neuroprotective efficacy of plumbagin against I/R-induced brain injury via effectively modulating apoptotic pathways, MMPs and neuroinflammatory cascades
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xiao Juan& Zhang, Jian Guo& Wu, Lan. 2018. Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-a NF-jB pathway induced inflammation and matrix metalloproteinase-2 9 expression in rat cerebral ischemia. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1033-1039.
https://search.emarefa.net/detail/BIM-851808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xiao Juan…[et al.]. Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-a NF-jB pathway induced inflammation and matrix metalloproteinase-2 9 expression in rat cerebral ischemia. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1033-1039.
https://search.emarefa.net/detail/BIM-851808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xiao Juan& Zhang, Jian Guo& Wu, Lan. Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-a NF-jB pathway induced inflammation and matrix metalloproteinase-2 9 expression in rat cerebral ischemia. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1033-1039.
https://search.emarefa.net/detail/BIM-851808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1038-1039
رقم السجل
BIM-851808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر