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Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) robinson in experimental animal model
المؤلفون المشاركون
Abu al-Farah, Muhammad
Sadiqi, Shah Alam
Rahman, M. Oliur
Akbar, Muhammad Ahsanul
Rauf, A. S. Shamsur
Ali, Muhammad Ajmal
al-Hamid, Fahd M. A.
Rahman, Atiqur
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 6 (30 سبتمبر/أيلول 2018)، ص ص. 1049-1055، 7ص.
الناشر
تاريخ النشر
2018-09-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Mikania cordata is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh.
In the present study, essential oil (12.5, 25 and 50 mg/kg) and two extracts, viz., chloroform and ethyl acetate extracts (200, 400, 800 mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by acetic acid-induced writhing and hot plate method, respectively.
Carrageenan-induced rat paw edema assay and yeast-induced hyperthermia assay were also carried out to evaluate anti-inflammatory and antipyretic properties of oil and extracts, respectively at aforesaid doses.
The essential oil (50 mg/kg), chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed potent peripheral antinociceptive activity having 47.33%, 29.33% and 16.65% of writhing inhibition, respectively, comparable with standard diclofenac (52.0%).
Essential oil (50 mg/kg), chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) presented promising central anti-nociceptive activity as well having 95.86%, 79.18% and 42.37% elongation of reaction time, respectively, at 90 min after administration of essential oil, ethyl acetate extract and 60 min after administration of chloroform extract.
In anti-inflammatory activity screening, the essential oil (50 mg/kg) produced the highest 72.80% edema inhibition at 4 h after administration of carrageenan which was comparable with that of standard phenylbutazoe (87.87%).
On the other hand, chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed up to 34.31% and 15.27% of edema inhibition, respectively, at 4 h after administration of carrageenan.
In antipyretic assay, the essential oil and chloroform extract displayed a strong antipyretic effect in yeastinduced rats, whereas the ethyl acetate extract had no antipyretic activity.
The present study revealed anti-nociceptive, anti-inflammatory and antipyretic potential of M.
cordata which could be the therapeutic option against fever, inflammations as well as painful conditions and confirmed the traditional use of M.
cordat
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadiqi, Shah Alam& Rahman, Atiqur& Rahman, M. Oliur& Akbar, Muhammad Ahsanul& Rauf, A. S. Shamsur& Ali, Muhammad Ajmal…[et al.]. 2018. Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) robinson in experimental animal model. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1049-1055.
https://search.emarefa.net/detail/BIM-851811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadiqi, Shah Alam…[et al.]. Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) robinson in experimental animal model. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1049-1055.
https://search.emarefa.net/detail/BIM-851811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadiqi, Shah Alam& Rahman, Atiqur& Rahman, M. Oliur& Akbar, Muhammad Ahsanul& Rauf, A. S. Shamsur& Ali, Muhammad Ajmal…[et al.]. Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) robinson in experimental animal model. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1049-1055.
https://search.emarefa.net/detail/BIM-851811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1055
رقم السجل
BIM-851811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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