Synthesis, characterization and study of biological activity of some new schiff bases, 1, 3-oxazepine and tetrazole derived from 2, 2 di thiophenyl acetic acid
المؤلفون المشاركون
المصدر
Ibn al-Haitham Journal for Pure and Applied Science
العدد
المجلد 31، العدد 1 (30 إبريل/نيسان 2018)، ص ص. 189-202، 14ص.
الناشر
جامعة بغداد كلية التربية ابن الهيثم
تاريخ النشر
2018-04-30
دولة النشر
العراق
عدد الصفحات
14
الملخص EN
In this study new derivatives of Schiff bases 5-8 , 1,3- oxazepine 9-16 and tetrazoles 17- 19 have been synthesized from the new starting material 1 which has synthesized the reaction of one mole of dichloro acetic acid and two moles of thiophenol , the esters 2-3 were synthesized from the reaction of compound 1 with methanol or ethanol respectively in the presence of H2SO4 as catalyst then 2,2-dithiophenylaceto Hydrazide 4 were synthesized from the reaction of 2 or 3 with hydrazine hydrate 80 % , Schiff bases 5-8 were synthesized from the reaction of 4 with appropriate aldehyde or ketone .Treatment of Schiff bases with maleic and phathalic anhydride in dry benzene to give 1,3-oxazepen derivatives 9-16 and with sodium azide in tetrahydrofuran (THF) afforded tetrazole derivatives 17-19.
All these compounds have been characterized from their melting pointes, FTIR, 1 HNMR and compounds 1,5 and 18 by mass spectrometry.
Derivatives 6,7,11,16,17 and 18 were tested against inhibition of E.
coli and.
Staphylococcus- aureus and were all funds to be active.
Scheme (1).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Husayn, Iman M.& Naji, Husam Z.. 2018. Synthesis, characterization and study of biological activity of some new schiff bases, 1, 3-oxazepine and tetrazole derived from 2, 2 di thiophenyl acetic acid. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 31, no. 1, pp.189-202.
https://search.emarefa.net/detail/BIM-852917
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Husayn, Iman M.& Naji, Husam Z.. Synthesis, characterization and study of biological activity of some new schiff bases, 1, 3-oxazepine and tetrazole derived from 2, 2 di thiophenyl acetic acid. Ibn al-Haitham Journal for Pure and Applied Science Vol. 31, no. 1 (2018), pp.189-202.
https://search.emarefa.net/detail/BIM-852917
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Husayn, Iman M.& Naji, Husam Z.. Synthesis, characterization and study of biological activity of some new schiff bases, 1, 3-oxazepine and tetrazole derived from 2, 2 di thiophenyl acetic acid. Ibn al-Haitham Journal for Pure and Applied Science. 2018. Vol. 31, no. 1, pp.189-202.
https://search.emarefa.net/detail/BIM-852917
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 201-202
رقم السجل
BIM-852917
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر