Could metformin be used as a treatment for preeclampsia : a pilot study
المؤلفون المشاركون
Abd al-Alim, Hani
Shamash, Ayman H.
Abd al-Azim, Hanan G.
Makhluf, Ala M.
Shaban, Umar M.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 3، العدد 1 (30 إبريل/نيسان 2018)، ص ص. 37-42، 6ص.
الناشر
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective To test the effect of metformin on serum level of antiangiogenic factors, soluble endoglin (sEng) and soluble fms‑like tyrosine kinase‑1 (sFLT‑1), in patients with preeclampsia (PE).
Patients and methods A controlled before and after prospective study was conducted on 40 patients with nonsevere PE conducted in a tertiary hospital setting.
At admission, clinical and laboratory investigations had been done.
Metformin tablets (500 mg three times daily) with meals were given from the time of study admission till delivery or termination of pregnancy.
Serum level of sEng and sFLT‑1 were measured before and 1 week after metformin treatment.
Outcome of delivery had been obtained.
Results One week after metformin treatment, there was a statistically significant reduction in maternal sEng and sFLT‑1, with a mean difference of −448.86 ± 238.48 and −397.72 ± 125.52 pg/ml, respectively.
In addition, there were significant reductions in both systolic blood pressure from 147 ± 12.4 to 131 ± 10.6 mmHg and diastolic blood pressure from 92 ± 7 to 85 ± 8.2 mmHg 1 week after metformin use.
Five (12.5%) cases progressed to severe PE.
Conclusion Metformin use for 1 week reduces the antiangiogenic biomarkers sEng and sFLT‑1, and it could have a role in the treatment of PE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Alim, Hani& Shamash, Ayman H.& Abd al-Azim, Hanan G.& Makhluf, Ala M.& Shaban, Umar M.. 2018. Could metformin be used as a treatment for preeclampsia : a pilot study. Journal of Current Medical Research and Practice،Vol. 3, no. 1, pp.37-42.
https://search.emarefa.net/detail/BIM-853330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Alim, Hani…[et al.]. Could metformin be used as a treatment for preeclampsia : a pilot study. Journal of Current Medical Research and Practice Vol. 3, no. 1 (Jan. / Apr. 2018), pp.37-42.
https://search.emarefa.net/detail/BIM-853330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Alim, Hani& Shamash, Ayman H.& Abd al-Azim, Hanan G.& Makhluf, Ala M.& Shaban, Umar M.. Could metformin be used as a treatment for preeclampsia : a pilot study. Journal of Current Medical Research and Practice. 2018. Vol. 3, no. 1, pp.37-42.
https://search.emarefa.net/detail/BIM-853330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 41-42
رقم السجل
BIM-853330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر