The role of histone H3K27 dimethylation in early-stage urinary bladder carcinoma : the relevance of risk factor
المؤلفون المشاركون
Jabir, Marwah A.
Rizq, Khalid M.
Hamid, Samiyah F.
Salamah, Raja H. M.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 3، العدد 2 (31 أغسطس/آب 2018)، ص ص. 93-99، 7ص.
الناشر
تاريخ النشر
2018-08-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background Epigenetic alterations, including post-translational modification of histone tails by methylation may play an important role in carcinogenesis.
Objective The aim was to evaluate the global histone H3K27 dimethylation (H3K27me2) levels in bladder cancer (BC) and to compare these levels in different types and stages of BC.
Materials and Methods Venous blood from 45 BC patients and 45 apparently healthy controls was used.
The two risk factors such as Schistosoma haematobium infection and smoking were investigated.
Histone extraction was done and used to determine the global levels of H3K27 dimethylation.
Results Global level of H3K27 dimethylation was significantly lower in BC patients than in healthy controls.
We observed a negative correlation between histone dimethylation levels and the smoking state (both in patients and controls).
Receiver operating characteristic curve showed that histone H3K27me2 at a cut‑off point less than 49.68 ng/l has 69% sensitivity and 64.5% specificity for the prediction of BC with an area under the curve of 0.67 (P = 0.001).
However, there was no statistically significant difference in H3K27me2 levels as regards history of S.
haematobium infection (P = 0.6), histopathological types (P = 0.3), and the stages of cancer (P = 0.8).
Conclusion The global histone H3K27 dimethylation may substantiate the potential to improve the detection of early‑stage urinary bladder carcinoma.
Also, the decreased level of histone H3K27me2 in smokers (either patients or controls) could be one entity that explain smoking as a risk factor for BC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salamah, Raja H. M.& Jabir, Marwah A.& Rizq, Khalid M.& Hamid, Samiyah F.. 2018. The role of histone H3K27 dimethylation in early-stage urinary bladder carcinoma : the relevance of risk factor. Journal of Current Medical Research and Practice،Vol. 3, no. 2, pp.93-99.
https://search.emarefa.net/detail/BIM-853554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salamah, Raja H. M.…[et al.]. The role of histone H3K27 dimethylation in early-stage urinary bladder carcinoma : the relevance of risk factor. Journal of Current Medical Research and Practice Vol. 3, no. 2 (May. / Aug. 2018), pp.93-99.
https://search.emarefa.net/detail/BIM-853554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salamah, Raja H. M.& Jabir, Marwah A.& Rizq, Khalid M.& Hamid, Samiyah F.. The role of histone H3K27 dimethylation in early-stage urinary bladder carcinoma : the relevance of risk factor. Journal of Current Medical Research and Practice. 2018. Vol. 3, no. 2, pp.93-99.
https://search.emarefa.net/detail/BIM-853554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 98-99
رقم السجل
BIM-853554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر