Schsitosoma mansoni co-infection with hepatitis c virus is associated with increased interleukin-28b plasma levels in egyptian population
المؤلفون المشاركون
Id, Samirah Z. A.
Abd al-Tawwab, Nurtan F.
Malak, Samuil T.
Amin, Majdi A.
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 47، العدد 2 (31 أغسطس/آب 2017)، ص ص. 363-374، 12ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2017-08-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Intestinal schistosomiasis and hepatitis C viral (HCV) infections are endemic in Egypt with co-infections leading to increased severity of liver diseases.
Previous studies characterized the im-mune responses to treatment in co-infection.
However, little is known about the levels of inter-leukin 28B (IL-28B) in co-infection and its relation to endogenous gamma interferon (IFN-y)levels.
Therefore, a case-control study was performed comparing levels of IL-28B in relation to endogenous IFN-y in Schistosoma mansoni / HCV co-infected Egyptian patients compared to HCV mono-infected patients.
Patients attending Kasr Al-Aini Hospital.
Cairo from 2012-2014 were recruited.
Subjects recruited were S.
mansoni/HCV co-infected (n=22).
treatment-naive chronic HCV-4 (n=50).
and healthy controls (n=35).
Clinical history and liver function markers were determined for each participant.
IL-2SB and IFN-y plasma levels were assayed for all par-ticipants by ELISA and HCV load was quantified using Real-Time PCR_ Plasma anti-schistosomal antibody titers were assayed along with viable egg identification in feces.
Patients with high HCV viral load had significantly higher IFN-y and IL-28B levels whether suffering from HCV mono- or co-infection.
Moreover.
IFN-y levels were positively associated with IL-28B plasma levels in HCV mono- and co-infection.
The IL-2SB levels were significantly higher in S.
mansoni/HCV co-infected than HCV mono-infection patients (p < 0.05).Data suggested that co-infection of HCV with S.
mansoni affected IL-2SB levels and IL-28B plasma levels might prove with sufficient further studies to be an effective prognosis biomarker for S.
mansoni ! HCV co-infection in the Egyptian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Id, Samirah Z. A.& Abd al-Tawwab, Nurtan F.& Malak, Samuil T.& Amin, Majdi A.. 2017. Schsitosoma mansoni co-infection with hepatitis c virus is associated with increased interleukin-28b plasma levels in egyptian population. Journal of the Egyptian Society of Parasitology،Vol. 47, no. 2, pp.363-374.
https://search.emarefa.net/detail/BIM-857781
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Id, Samirah Z. A.…[et al.]. Schsitosoma mansoni co-infection with hepatitis c virus is associated with increased interleukin-28b plasma levels in egyptian population. Journal of the Egyptian Society of Parasitology Vol. 47, no. 2 (Aug. 2017), pp.363-374.
https://search.emarefa.net/detail/BIM-857781
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Id, Samirah Z. A.& Abd al-Tawwab, Nurtan F.& Malak, Samuil T.& Amin, Majdi A.. Schsitosoma mansoni co-infection with hepatitis c virus is associated with increased interleukin-28b plasma levels in egyptian population. Journal of the Egyptian Society of Parasitology. 2017. Vol. 47, no. 2, pp.363-374.
https://search.emarefa.net/detail/BIM-857781
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 371-374
رقم السجل
BIM-857781
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر