Assessment of the effect of long term in halation of corticosteroids(ICS)‎ for asthma control in children on fat distribution and bone density

الملخص EN

Background: Inhaled corticosteroid (ICS) are the most effective anti inflammatory medication for the treatment of persistent asthma).

Objective: To assess the effect of long term inhalation of corticosteroid (ICS) for asthma control in children on body fat distribution and bone density.

Patients: The study included 120 children aged (5-10) years, they were classified into 3 groups.

Group I, 40 moderately asthmatic children on low doses of (ICS).

Group II, 40 severely asthmatic children on medium to high doses of (ISC).

Group I and II comprised the patients group that were collected from allergy outpatient clinic of children hospital, Cairo university from the period between September 2016 and April 2017.

Group III, 40 healthy control children of comparable age and sex Methods: All children were subjected full history, clinical examination radiological studies, anthropometric measurements (weight, height mid upper arm, waist and hip circumference) as well as bone mineral density (BMD) assessed by The body mass index (BM1) was also calculated Dexa (Duel Energy X ray Absorptiometry) at lumber spines L2- L4 levels.

Results: There is no significant difference in anthropometric measurements including body fat distribution as well as BMD in all studied groups, A positive correlation was found between BMD, duration of illness, dose of ICS, asthma symptoms and anthropometric measurements.