Effect of policosanol extract and simvastatin on some liver enzymes and histopathology in hypercholestrolemic female rats during lactation

الملخص EN

Hypercholesterolemia is usually known as the presence of high levels of cholesterol in the blood.

Cholesterol is an amphipathic lipid and is naturally existed in the tissues and the plasma.

In the plasma, it is carried in lipoproteins.

These lipoproteins are High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoproteins- Cholesterol (LDL-C), Very Low Density Lipoprotein- Cholesterol (VLDL), and chylomicrons.

The last three groups are closely related with the hazard of coronary heart disease (CHD), whereas (HDL-C) is not.Policosanol is a mixture produces from extraction of sugar cane wax (Saccharumofficinarum , this mixture shows cholesterol lowering and antiplatelet effects, and is being used as hypocholesterolemic drug.