Estimate antimicrobial activity and anti-biofilm formation of bark cinnamomum zeylanicum on klebsiella pneumoniae isolated from urinary tract infections

الملخص EN

Five isolates (25%) of klebsiella pneumoniae were isolated from urine samples.

in addition also isolated bacteria were (10) 50% escherichia coli, while (3)15% proteus spp., (2)10% pseudomonas aeruginosa.

the ethanolic extract of cinnamomum zeylanicum bark were tested against klebsiella pneumoniae by using the well agar diffusion test, the alcoholic bark extract from (200 -12.5) mg/ml possessed antimicrobial activity against tested microorganism.

at 200 mg/ml, and 100 mg/ml concentrations was diameter of inhibition zone rang from (18-26mm), (14-16mm) respectively, and these results compared to antibiotics norfloxacin(10μg) inhibition zone (24-30mm), and cefotaxim (10 μg) (26-27mm) as control.

antibiotics sensetivity were used ten antibiotics with disc diffusion method against k.

pneumoniae, they were sensitive to cefotaxime, imipenem /cilactin,sparfloxacin, and norfloxacin antibiotics only, and were resisted to the others antibiotics.

minimum inhibitory concentration was tested for plant extract, and was ranged versus klebsiella pneumoniae (12.5-25) mg/ml.

it could be concluded that alcoholic extract of cinnamomum zeylanicum had a good antimicrobial effects and anti-biofilm on klebsiella pneumoniae with significant difference (p< 0.05).

this caused a decrease in the biofilm of the tested bacteria.

hence, it may be used instead of antibiotics to treat utis caused by bacteria used in current study.