Reduced severe and symptomatic hypoglycemic episodes in adolescents with type 1 diabetes using long acting insulin analogs
المؤلفون المشاركون
al-Tawil, Muhammad
Salim, Muna A.
al-Habashi, Safinaz A.
Abu Shadi, Nansi M.
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 23، العدد 1-2 (30 يونيو/حزيران 2005)، ص ص. 175-189، 15ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2005-06-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الموضوعات
الملخص EN
Insulin Glargine ( GlyA21-ArgBa30-ArgBb30 ), is a biosynthetic basal insulin analog with a prolonged duration of action ( about 24 hours ) without peaks of plasma insulin levels.
This study evaluated the efficiency and safety of Insulin glargine in subjects with type 1 diabetes compared to NPH, as basal insulin therapy in type 1 diabetes mellitus, regarding the degree of glycemic control (glycosylated Hb & fasting blood glucose), hypoglycemic episodes, required insulin dose and local reactions.
Thirty five Egyptian adolescents with type 1 diabetes were randomized to receive premeal regular insulin and basal insulin, either insulin glargine ( at bedtime ) or NPH Insulin ( Twice daily ) for up to 6 months.
Dose titration of both basal insulins was based on capillary fasting blood glucose( FBG ) levels; the goal was a premeal blood glucose concentration of 80-120 mg / dl.
Results revealed that, both treatment groups (glargine & NPH), were comparable regarding age, diabetes duration, mean FBG, glycosylated Hb (HbA1c %) and required insulin dose, at the start of the study.
Throughout the 6 months study duration, insulin glargine group showed more mean reduction in HbA1c% (2.3%), compared to NPH insulin group (1.4%), however, the difference was statistically insignificant (p=0.28).
Also, there was no significant.
Difference between both groups Reduced Severe And Symptomatic regarding mean change of insulin dose or number of local reactions.
Both types of insulin were comparable regarding total and nocturnal hypoglycemic episodes, however, significantly fewer severe (p = 0.02) and symptomatic (p = 0.03) hypoglycemic episodes occurred in glargine compared to NPH group.
In conclusion, Insulin Glargine once a day appears to be as safe and as effective as NPH insulin twice a day in maintaining glycemic control in patients with type 1 diabetes with less frequent severe and symptomatic hypoglycemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salim, Muna A.& al-Habashi, Safinaz A.& al-Tawil, Muhammad& Abu Shadi, Nansi M.. 2005. Reduced severe and symptomatic hypoglycemic episodes in adolescents with type 1 diabetes using long acting insulin analogs. Egyptian Journal of Applied Endocrinology،Vol. 23, no. 1-2, pp.175-189.
https://search.emarefa.net/detail/BIM-87760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salim, Muna A.…[et al.]. Reduced severe and symptomatic hypoglycemic episodes in adolescents with type 1 diabetes using long acting insulin analogs. Egyptian Journal of Applied Endocrinology Vol. 23, no. 1-2 (Jun. 2005), pp.175-189.
https://search.emarefa.net/detail/BIM-87760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salim, Muna A.& al-Habashi, Safinaz A.& al-Tawil, Muhammad& Abu Shadi, Nansi M.. Reduced severe and symptomatic hypoglycemic episodes in adolescents with type 1 diabetes using long acting insulin analogs. Egyptian Journal of Applied Endocrinology. 2005. Vol. 23, no. 1-2, pp.175-189.
https://search.emarefa.net/detail/BIM-87760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 184-186
رقم السجل
BIM-87760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر