Association of matrix metalloproteinase-1-1607 1G 2G and C-reactive protein -717 C T gene polymorphisms in Iranian patients with chronic periodontitis : a clinical trial
المؤلفون المشاركون
Vahabi, Surena
Nazemisalman, Bahareh
Kalantari, Mahsa
Hosseinpour, Sepanta
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2019-01-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: An imbalance in the expression of matrixmetalloproteinases (MMPs) and tissue inhibitormetalloproteinases initiate the destructive process in chronic periodontitis (CP).
C-reactive protein (CRP) is a systemic inflammatory mediator that reflects an acute immune response.
Objectives: The purpose of this investigation was to analyze the association between the MMP-1 -1607 1G/2G (rs1799750) and CRP 717 A/G (rs2794521) gene polymorphisms and chronic periodontitis in Iran.
Methods: This analytical case-control study was performed among 141 participants including 63 CP cases and 78 matched healthy individuals.
Five milliliters of peripheral blood was collected for DNA isolation.
Restriction fragment length polymorphism- polymerase chain reaction (RFLP-PCR) was performed for single-nucleotide polymorphism (SNP) analysis.
The frequencies were analyzed by chi-squared test (95% CI, P < 0.05).
In addition, genetic data were assessed by the Hardy-Weinberg principle, linkage disequilibrium, and haplotype analysis.
Results: Our findings presented no significant relationship between genotype/alleles of MMP-1 -1607 1G/2G (rs1799750) (0.73: 0.27 - 1.95, P = 0.48) or CRP 717 A/G (rs2794521) (0.384: 0.104 - 1.414, P = 0.303) and the presence of CP (P = 0.47 and P = 0.30, respectively).
The analysis of genetic distribution among various severities of CP and controls revealed no significant association between various severities of CP and MMP-1 -1607 1G/2G (rs1799750) (P = 0.52) and CRP 717 A/G (rs2794521) (P = 0.67).
Conclusions: Our results suggest no association between the occurrence or severity of chronic periodontitis and MMP-1 -1607 1G/2G (rs1799750) and CRP 717 A/G (rs2794521) polymorphisms.
Further studies with larger sample sizes may provide a more generalizable evidence-based overview of the relationship between these gene polymorphisms and periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vahabi, Surena& Nazemisalman, Bahareh& Kalantari, Mahsa& Hosseinpour, Sepanta. 2019. Association of matrix metalloproteinase-1-1607 1G 2G and C-reactive protein -717 C T gene polymorphisms in Iranian patients with chronic periodontitis : a clinical trial. Iranian Red Crescent Medical Journal،Vol. 21, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-883639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vahabi, Surena…[et al.]. Association of matrix metalloproteinase-1-1607 1G 2G and C-reactive protein -717 C T gene polymorphisms in Iranian patients with chronic periodontitis : a clinical trial. Iranian Red Crescent Medical Journal Vol. 21, no. 1 (Jan. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-883639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vahabi, Surena& Nazemisalman, Bahareh& Kalantari, Mahsa& Hosseinpour, Sepanta. Association of matrix metalloproteinase-1-1607 1G 2G and C-reactive protein -717 C T gene polymorphisms in Iranian patients with chronic periodontitis : a clinical trial. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-883639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-883639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر