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Increased expression of mir-1 in fast-twitch skeletal muscle in response to resistance exercise
المؤلفون المشاركون
Gharakhanlou, Rida
Sulaymani, Masud
Rajabi, Hamid
Fathi, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 4 (30 إبريل/نيسان 2019)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2019-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: The response of microRNA (miR-1), upstream regulators (Myogenic Differentiation 1 (MyoD1) and Myocyte Enhancer Factor 2C (Mef2C)), and a downstream target (Histone Deacetylase 4 (Hdac4)) to an acute bout of Resistance Exercise (RE) in Extensor Digitorum Longus (EDL) and soleus muscles has remained elusive.
Objectives: In this experimental study, we investigated the effect of an acute bout of RE on the expression of miR-1, MyoD1, Mef2C, and Hdac4 genes in the slow and fast-twitch muscle of rats.
Methods: The current study was conducted at Tarbiat Modares University, Tehran, Iran, in 2017.
Fifteen male Wistar rats were randomly divided into two groups, control (n = 5) and RE (n = 10).
The RE protocol consisted of four sets of five repetitions of climbing a ladder with weights attached to the tails of rats.
The soleus and EDL muscles of rats were collected at 3 h (n = 5) and 6 h (n = 5) post-RE.
The real-time polymerase chain reaction was used to measure the levels of miR-1, MyoD1, Mef2C, and Hdac4 mRNA expression.
Results: The miR-1 expression in EDL muscle was significantly lower at 3 h and 6 h post-exercise in the RE group than in the control group (P < 0.01).
The miR-1 expression in soleus muscle was significantly lower at 3 h post-exercise in the RE group than in the control group (P < 0.007) but it was significantly higher at 6 h post-exercise (P < 0.036).
The expression of MyoD1, Mef2C, and Hdac4 genes in the EDL muscle was higher in the RE group than in the control group (P < 0.01).
The expression of these genes in response to RE had more fluctuations in soleus muscle.
Conclusions: It can be concluded that miR-1 expression in extensor digitorum longus and soleus muscles of rats responds to resistance exercise in different manners and this coincides with a change in upstream regulators and downstream target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fathi, Muhammad& Gharakhanlou, Rida& Sulaymani, Masud& Rajabi, Hamid. 2019. Increased expression of mir-1 in fast-twitch skeletal muscle in response to resistance exercise. Iranian Red Crescent Medical Journal،Vol. 21, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-883771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fathi, Muhammad…[et al.]. Increased expression of mir-1 in fast-twitch skeletal muscle in response to resistance exercise. Iranian Red Crescent Medical Journal Vol. 21, no. 4 (Apr. 2019), pp.1-8.
https://search.emarefa.net/detail/BIM-883771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fathi, Muhammad& Gharakhanlou, Rida& Sulaymani, Masud& Rajabi, Hamid. Increased expression of mir-1 in fast-twitch skeletal muscle in response to resistance exercise. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-883771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-883771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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