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Anti-proliferative effects of two new lactobacillus strains of human origin on caco-2 cell Line
المؤلفون المشاركون
Arian, Simin
Kaboosi, Hami
Heshmatipour, Zahir
Khazaei Koohpar, Zaynab
Pyravii Ghadikolaii, Fatimah
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 3 (31 مارس/آذار 2019)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2019-03-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Anti-proliferative effects of probiotics are considerable in the treatment of various cancers, including colon cancer.
In the present study, two new Lactobacillus strains as probiotics were isolated from stool samples at a clinical lab.
Objectives: The aim of this study was to evaluate the effects of the cell-free lyophilized filtrate of two new strains of Lactobacillus, isolated on viability on Caco-2 cells.
Methods: Two new strains of Lactobacillus were isolated from 1 gr of each infant stool specimens from a total of fifty volunteers, according to the principles of a scientific questionnaire.
The anti-proliferative effects of the strains were investigated using the MTT assay with Caco-2 cell lines.
Results: Out of 50 samples, seven isolates were lactic acid bacteria, two strains of which were probiotics related to L.
fermentum (E) and L.
rhamnosus (G).
The results showed that the two Lactobacillus strains had good anti-proliferative effects against the cancer cell lines tested.
These strains were resistant to low pH and 0.3% bile salt.
Cytotoxicity assay revealed that the most effective concentration of strains E (~ 55% to ~ 72%) and G (~ 60% to ~ 80%) on Caco-2 cells was 10000 µg/mL after 24 to72 hours.
Conclusions: Cytotoxicity effect of the cell-free lyophilized filtrate of bacteria on Caco-2 cells in a dose- and time-dependent manner suggested that these strains might be used in colon cancer therapy
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arian, Simin& Kaboosi, Hami& Heshmatipour, Zahir& Khazaei Koohpar, Zaynab& Pyravii Ghadikolaii, Fatimah. 2019. Anti-proliferative effects of two new lactobacillus strains of human origin on caco-2 cell Line. Iranian Red Crescent Medical Journal،Vol. 21, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-886751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arian, Simin…[et al.]. Anti-proliferative effects of two new lactobacillus strains of human origin on caco-2 cell Line. Iranian Red Crescent Medical Journal Vol. 21, no. 3 (Mar. 2019), pp.1-8.
https://search.emarefa.net/detail/BIM-886751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arian, Simin& Kaboosi, Hami& Heshmatipour, Zahir& Khazaei Koohpar, Zaynab& Pyravii Ghadikolaii, Fatimah. Anti-proliferative effects of two new lactobacillus strains of human origin on caco-2 cell Line. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-886751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-886751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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