![](/images/graphics-bg.png)
Clinical significance of fibroblast growth factor-23 and soluble alpha klotho in different stages of chronic kidney disease
المؤلفون المشاركون
Khudayr, Sami A.
Uqdah, Hana I.
Abd al-Al, Hibah M.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 1 (28 فبراير/شباط 2019)، ص ص. 108-118، 11ص.
الناشر
تاريخ النشر
2019-02-28
دولة النشر
السعودية
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Most chronic kidney disease (CKD) biomarkers in the current clinical use are not sensitive enough and cannot be used to identify the early stage of the disease.
Klotho is a transmembrane protein predominantly expressed in the renal tubules and implicated in managing phosphate homeostasis, together with fibroblast growth factor-23 (FGF-23); a bone-derived protein that increases urinary phosphate excretion.
The present study was carried out on 50 patients CKD with different etiologies referred to the Internal Medicine Department and Out Patient Clinic of Tanta University Hospitals and 30 apparently healthy individuals of matched age and sex as a control group.
They were subjected to the following assessment: detailed history taking, careful clinical examination, and laboratory investigations, including urea, creatinine, estimated glomerular filtration rate (eGFR), serum electrolytes, urinary albumin, urinary phosphorus (U-Ph), and specific laboratory tests for: Alpha Klotho (α-klotho) and FGF-23 by using ELISA technique.
The present study shows that the mean value of serum creatinine, urea, phosphorus, urinary albumin, and FGF-23 were significantly increased, whereas there was a significant decrease in the mean value of eGFR, calcium, and U-Ph in the patients with CKD when compared with control group.
Plasma level of serum α-klotho is significantly decreased in all patients with CKD when compared to the control group and there was a significant positive correlation between serum α-klotho level and eGFR, serum calcium level and U-Ph level.
Plasma level of serum α-klotho is significantly decreased in all patients with CKD and serum α-klotho can be used as a good marker for early diagnosis and staging of CKD
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khudayr, Sami A.& Uqdah, Hana I.& Abd al-Al, Hibah M.. 2019. Clinical significance of fibroblast growth factor-23 and soluble alpha klotho in different stages of chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.108-118.
https://search.emarefa.net/detail/BIM-887119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khudayr, Sami A.…[et al.]. Clinical significance of fibroblast growth factor-23 and soluble alpha klotho in different stages of chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.108-118.
https://search.emarefa.net/detail/BIM-887119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khudayr, Sami A.& Uqdah, Hana I.& Abd al-Al, Hibah M.. Clinical significance of fibroblast growth factor-23 and soluble alpha klotho in different stages of chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.108-118.
https://search.emarefa.net/detail/BIM-887119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 117-118
رقم السجل
BIM-887119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)