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Green tea activity and iron overload induced molecular fibrogenesis of rat liver
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 3 (31 مارس/آذار 2019)، ص ص. 531-540، 10ص.
الناشر
تاريخ النشر
2019-03-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Iron overload toxicity was shown to associate with chronic liver diseases which lead to hepatic fibrosis and subsequently the progression to cancer through oxidative stress and apoptotic pathways.
Green tea potential activity as chelating, anti-oxidative, or anti-apoptotic mechanisms against metal toxicity was poorly clarified.
Here, we are trying to evaluate the anti-oxidant and anti-apoptotic properties of green tea in the regulation of serum hepcidin levels, reduction in iron overloads, and improve of liver fibrosis in iron overloaded experimental rats.
Three groups of male adult rats were randomly classified into three groups and treated as follows: control rats, iron treated rats for two months in drinking water followed by either vehicle or green tea extract (AGTE; 100 mg/kg) treatment for 2 more months.
Thereafter, we studied the effects of AGTE on iron overload-induced lipid peroxidation, anti-oxidant depletion, liver cell injury and apoptosis.
Treatment of iron-overloaded rats with AGTE resulted in marked decreases in iron accumulation within liver, depletion in serum ferritin, and hepcidin levels.
Iron-overloaded rats had significant increase in malonyldialdehyde (MDA), a marker of lipid peroxidation and nitric oxide (NO) in liver when compared to control group.
Also, significant change in cytochrome c and DNA content as apoptotic markers were reported in iron treated rats.
The effects of iron overload on lipid peroxidation, NO levels, cytochrome c and DNA content were significantly reduced by the intervention treatment with AGTE (P < 0.001).
Furthermore, the endogenous anti-oxidant capacities/levels (TAC) in liver were also significantly decreased in chronic iron overload and administration of AGTE restored the decrease in the hepatic antioxidant activities/levels.
Also, hepatic hepcidin was shown to be significantly correlated with oxidative and apoptotic relating biomarkers as well as an improvement in liver fibrosis of iron treated rats following AGTE treatment.
In-vitro analysis showed that, the improvement in iron toxicity of the liver depend mainly on antioxidant and protective ability of green tea polyphenolic compounds especiallyepigallocatechin-3-gallate (EGCG).
Our study showed that green tea extract (GTE) ameliorates iron overload induced hepatotoxicity, apoptosis and oxidative stress in rat liver via inhibition of hepatic iron accumulation; improve of liver antioxidant capacity, and down regulation of serum hepcidin as well as reduction in the release of apoptotic relating proteins
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Bashir, Ghadah I.. 2019. Green tea activity and iron overload induced molecular fibrogenesis of rat liver. Saudi Journal of Biological Sciences،Vol. 26, no. 3, pp.531-540.
https://search.emarefa.net/detail/BIM-887234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Bashir, Ghadah I.. Green tea activity and iron overload induced molecular fibrogenesis of rat liver. Saudi Journal of Biological Sciences Vol. 26, no. 3 (Mar. 2019), pp.531-540.
https://search.emarefa.net/detail/BIM-887234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Bashir, Ghadah I.. Green tea activity and iron overload induced molecular fibrogenesis of rat liver. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 3, pp.531-540.
https://search.emarefa.net/detail/BIM-887234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 538-540
رقم السجل
BIM-887234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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