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A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities
المؤلفون المشاركون
Abu al-Farah, Muhammad
Akbar, Muhammad Ahsanul
Ajmal Ali, Muhammad
Siddiqui, Shah Alam
Oliur Rahman, M.
al-Shaykh, M. S.
al-Hamid, Fahd M. A.
Rahman, Atiqur
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 3 (31 مارس/آذار 2019)، ص ص. 554-562، 9ص.
الناشر
تاريخ النشر
2019-03-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
The aerial parts of extensively used ethnomedicinal plant Mikania cordata (Burm.
f.) Robinson growing wild in Bangladesh were investigated to isolate and characterize compounds responsible for the bioactivities of the plant.
In the present study, a new derivatives of betulinic acid, 16-hydroxy betulinic acid [3 b,16-dihydroxy-lup-20(29)-en-28-oic] was isolated and the structure of the compound was determined by NMR spectroscopic means and comparing with available literature data.
The isolated compound was then investigated for different pharmacological activities including antibacterial, antifungal, analgesic, anti-inflammatory and antipyretic potential employing different methods.
The compound showed potent antibacterial activity with inhibition zone of diameter ranging from 12.0 to 17.5 mm and antifungal activity with mycelial growth inhibition ranging from 37.6 to 54.5%.
The MIC values for antibacterial and antifungal activities ranged from 31.5–125 and 250–1000 lg/mL respectively.
The compound (50 and 100 mg/kg body weight) showed potent peripheral and central analgesic activity with 55.19% and 41% of writhing inhibition at 90 min after administration of the compound and the highest 55.98%, 79.18% elongation of reaction time, respectively.
In anti-inflammatory activity screening, the compound (100 mg/kg b.
w.) revealed the highest 77.08% edema inhibition at 4 h after administration of carrageenan.
In antipyretic assay, 16-hydroxy betulinic acid displayed a strong antipyretic effect in yeast-induced rats.
From the present study it is apparent that 16-hydroxy betulinic acid might play vital role to establish M.
cordata as ethnomedicinal plant to treat wound, cuts and fever
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siddiqui, Shah Alam& Rahman, Atiqur& Oliur Rahman, M.& Akbar, Muhammad Ahsanul& Ajmal Ali, Muhammad& al-Hamid, Fahd M. A.…[et al.]. 2019. A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi Journal of Biological Sciences،Vol. 26, no. 3, pp.554-562.
https://search.emarefa.net/detail/BIM-887237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siddiqui, Shah Alam…[et al.]. A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi Journal of Biological Sciences Vol. 26, no. 3 (Mar. 2019), pp.554-562.
https://search.emarefa.net/detail/BIM-887237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siddiqui, Shah Alam& Rahman, Atiqur& Oliur Rahman, M.& Akbar, Muhammad Ahsanul& Ajmal Ali, Muhammad& al-Hamid, Fahd M. A.…[et al.]. A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 3, pp.554-562.
https://search.emarefa.net/detail/BIM-887237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 562
رقم السجل
BIM-887237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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