![](/images/graphics-bg.png)
Effect of sargentodoxa cuneata total phenolic acids on focal cerebral ischemia reperfusion injury rats model
المؤلفون المشاركون
Fang, Xiaoyan
Miao, Mingsan
Liu, Baosong
Peng, Mengfan
Jia, Jiaojiao
Bai, Ming
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 3 (31 مارس/آذار 2019)، ص ص. 569-576، 8ص.
الناشر
تاريخ النشر
2019-03-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective: Explore the possible protective effect of Sargentodoxa cuneata total phenolic acids on cerebral ischemia reperfusion injury rats.
Methods: Focal cerebral ischemia reperfusion rats model were established by linear thrombus.
Nimodipine group, Naoluotong group, the high, middle and low dose of Sargentodoxa cuneata total phenolic acids groups were given related drugs via intragastric administration before operation for seven days, once a day.
At the same time sham operation group, and ischemia reperfusion group were given the same volume of physiological saline.
One hour after the last administration, establish focal cerebral ischemia- reperfusion model in rats by thread method, and the thread was taken out after 2 h ischemia to achieve cerebral ischemia reperfusion injury in rats.
After reperfusion for 24 h, the rats were given neurologic deficit score.
The brain tissue was taken to measure the levels of IL-6, IL-1b, TNF-a, Bcl-2, Bax, Casp-3 and ICAM-1; HE staining observed histopathological changes in the hippocampus and cortical areas of the brain; Immunohistochemistry was used to observe the expression of NGF and NF-KBp65.
Result: Focal cerebral ischemia reperfusion rats model was copyed successed.
Compared with model group, each dose group of Sargentodoxa cuneata total phenolic acids could decreased the neurologic deficit score (P < 0.05 or P < 0.01), decreased the levels of IL-6, IL-1b, ICAM-1, TNF-a, Bax and Caspase-3 in brain tissue (P < 0.05 or P < 0.01), increased the levels of IL-10, Bcl-2, NGF in brain tissue (P < 0.05 or P < 0.01), decreased the express of NF-KBp65 in brain (P < 0.05 or P < 0.01).
Conclusion: Sargentodoxa cuneata total phenolic acids can improve focal cerebral ischemia reperfusion injury rats tissue inflammation, apoptosis pathway, increase nutrition factor to protect the neurons, reduce the apoptosis of nerve cells, activate brain cells self-protect, improve the histopathological changes in the hippocampus and cortical areas of the brain, reduce cerebral ischemia reperfusion injury
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Ming& Liu, Baosong& Peng, Mengfan& Jia, Jiaojiao& Fang, Xiaoyan& Miao, Mingsan. 2019. Effect of sargentodoxa cuneata total phenolic acids on focal cerebral ischemia reperfusion injury rats model. Saudi Journal of Biological Sciences،Vol. 26, no. 3, pp.569-576.
https://search.emarefa.net/detail/BIM-887239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Ming…[et al.]. Effect of sargentodoxa cuneata total phenolic acids on focal cerebral ischemia reperfusion injury rats model. Saudi Journal of Biological Sciences Vol. 26, no. 3 (Mar. 2019), pp.569-576.
https://search.emarefa.net/detail/BIM-887239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Ming& Liu, Baosong& Peng, Mengfan& Jia, Jiaojiao& Fang, Xiaoyan& Miao, Mingsan. Effect of sargentodoxa cuneata total phenolic acids on focal cerebral ischemia reperfusion injury rats model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 3, pp.569-576.
https://search.emarefa.net/detail/BIM-887239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 576
رقم السجل
BIM-887239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)