A size and time-dependent induction of proinflammatory cytokines expression in brains of mice treated with gold nanoparticles
المؤلفون المشاركون
al-Najjar, Dua M.
Ibrahim, Khalid E.
al-Amiri, Salman
Rusop, Muhammad
al-Rukayan, Salman H.
Khan, Hasib A.
al-Harbi, Najla
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 3 (31 مارس/آذار 2019)، ص ص. 625-631، 7ص.
الناشر
تاريخ النشر
2019-03-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Gold nanoparticles (GNPs) are among the ideal nano-sized materials for medical applications such as imaging and drug delivery.
Considering the significance of recent reports on acute phase induction of inflammatory mediators by GNPs, we studied the effect of GNPs on proinflammatory cytokines gene expression in mouse brain.
Group 1 served as control whereas groups 2–4 were given only one intraperitoneal dose of 5, 20 and 50 nm GNPs, respectively and sacrificed after 24 h.
The animals in groups 5–7 also received the same treatment but sacrificed after 7 days.
Groups 8–10 received two injections of GNPs (5, 20 and 50 nm, respectively), first at the beginning of study and second on day 6, and sacrificed on day 7.
Total RNA was extracted from the cerebral tissue and analyzed for the gene expressions of IL-1b, IL-6 and TNF-a.
A single injection of 5 nm diameter GNPs significantly increased the mRNA expression of IL-1b and IL-6 in mouse brain on day 7, which was not augmented by the second dose of the same GNPs.
Larger size GNPs (20 nm and 50 nm) did not cause any significant change in the expression of proinflammatory cytokines in mouse brain.
In conclusion, systemic administration of small sized GNPs (5 nm) induced a proinflammatory cascade in mouse brain indicating a crucial role of GNPs size on immune response.
It is important to use the right sized GNPs in order to avoid an acute phase inflammatory response that could be cytotoxic or interfere with the bioavailability of nanomaterials
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Hasib A.& al-Amiri, Salman& Ibrahim, Khalid E.& al-Najjar, Dua M.& al-Harbi, Najla& Rusop, Muhammad…[et al.]. 2019. A size and time-dependent induction of proinflammatory cytokines expression in brains of mice treated with gold nanoparticles. Saudi Journal of Biological Sciences،Vol. 26, no. 3, pp.625-631.
https://search.emarefa.net/detail/BIM-887247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Hasib A.…[et al.]. A size and time-dependent induction of proinflammatory cytokines expression in brains of mice treated with gold nanoparticles. Saudi Journal of Biological Sciences Vol. 26, no. 3 (Mar. 2019), pp.625-631.
https://search.emarefa.net/detail/BIM-887247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Hasib A.& al-Amiri, Salman& Ibrahim, Khalid E.& al-Najjar, Dua M.& al-Harbi, Najla& Rusop, Muhammad…[et al.]. A size and time-dependent induction of proinflammatory cytokines expression in brains of mice treated with gold nanoparticles. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 3, pp.625-631.
https://search.emarefa.net/detail/BIM-887247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 630-631
رقم السجل
BIM-887247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر