Design and synthesis of palladium (II)‎ OCO pincer type complexes and their catalytic role towards the a-arylation of ketones

الملخص EN

Twelve OCO bisacetamide ligands 4aa-4dc were synthesized after condensation of isophenylenediamines 1a-1d and anhydride/acyl chlorides.

The corresponding Pd(II)–OCO–H(5aa-5ac), Pd(II)–OCO–Me(5ba-5bc), Pd(II)–OCO–OMe(5ca-5 cc), Pd(II)–OCO–NO2(5da-5dc) pincer complexes were prepared via C-H activation of precursors and Pd(OAc)2, and characterized by IR, 1H NMR, 13C NMR and elemental analysis.

The α-arylation of ketones and aryl bromides catalyzed by 5 under low catalyst loadings (0.1 mol%) show that 5da exhibits the highest catalytic activity, resulting in a 98% isolated yield.