Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidinconnected 2-thioxoimidazolidin-4-one derivatives
المؤلفون المشاركون
Kumar, Radhakrishnan Surendra
Id Allah, Akbar
Arif, Ibrahim Abd al-Wahid
Ahmad, Anis
Manilal, Asir
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 4 (31 مايو/أيار 2019)، ص ص. 673-680، 8ص.
الناشر
تاريخ النشر
2019-05-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study was to investigate brine shrimp cytotoxicity, larvicidal, nematicidal, and antifeedant activities of novel piperidin-connected 2-thioxo-imidazolidin-4-one derivatives.
The activities of target compounds were compared with some naturally occurring (_)-pinidinol, hydantocidin, and positive controls.
Target compounds were synthesized via cyclocondensation method.
The compounds were synthesized and then characterized by infrared spectroscopy, 1H NMR, 13C NMR, mass spectral, and elemental analyses.
Brine shrimp cytotoxicity assay was investigated using freshly hatched, free-swimming nauplii of Artemiasalina.
Larvicidal screening was performed against urban mosquito larvae (Culex quinquefasciatus).
Nematicidal activity was evaluated using juvenile nematodes of Meloidogyne javanica.
Regarding antifeedant activity, marine-acclimated Oreochromis mossambicus fingerlings were used.
Compounds 3a-c (piperidin-connected 2-thioxoimidazolidin-4-one) were found to be lethal to the second instar larvae of mosquito, which produced LD50 values of 1.37, 6.66, 6.51 lg/mL, compared to compounds (_) pinidinol and hyantocidin LD50 values of 18.28 and 22.11 lg/mL respectively.
Compound 3a-c was found to kill 100 % of fish fingerlings within 6 h at 20 mg/mL, with LD50 values of 1.54, 1.79, 1.52 mg/mL, compared to compounds (_) pinidinol and hyantocidin with LD50 values of 10.21 and 21.05 lg/mL respectively.
Compound 3c with LD50 value of 1.57 lg/mL demonstrated high nematicidal activity compared to compound 3a, 3b, (_) Pinidinol and Hyantocidin LD50 values of 6.45, 2.42, 14.25, 26.30 lg / mL respectively.
Therefore, the 2-thioxoimidazolidin-4-one with piperidin ring showed high potential cytotoxic, larvicidal, nematicidal, and antifeedent activities.
_ 2017 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arif, Ibrahim Abd al-Wahid& Ahmad, Anis& Kumar, Radhakrishnan Surendra& Id Allah, Akbar& Manilal, Asir. 2019. Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidinconnected 2-thioxoimidazolidin-4-one derivatives. Saudi Journal of Biological Sciences،Vol. 26, no. 4, pp.673-680.
https://search.emarefa.net/detail/BIM-891115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arif, Ibrahim Abd al-Wahid…[et al.]. Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidinconnected 2-thioxoimidazolidin-4-one derivatives. Saudi Journal of Biological Sciences Vol. 26, no. 4 (May. 2019), pp.673-680.
https://search.emarefa.net/detail/BIM-891115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arif, Ibrahim Abd al-Wahid& Ahmad, Anis& Kumar, Radhakrishnan Surendra& Id Allah, Akbar& Manilal, Asir. Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidinconnected 2-thioxoimidazolidin-4-one derivatives. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 4, pp.673-680.
https://search.emarefa.net/detail/BIM-891115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 679-680
رقم السجل
BIM-891115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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