Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection
المؤلفون المشاركون
al-Arifi, S. M.
al-Kahtani, Sad Ali
Nazir, Nyla
Abdu, Ayman A.
al-Issia, Muhammad S.
al-Yahya, Hamad
al-Yahya, Hamad
Ali, Dawud Salman
al-Kahtani, Abd Allah A.
al-Anazi, Mashael R.
al-Qahtani, Ahmed A.
Sanai, Faisal M.
al-Ahdal, Muhammad N.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 2 (28 فبراير/شباط 2019)، ص ص. 270-280، 11ص.
الناشر
تاريخ النشر
2019-02-28
دولة النشر
السعودية
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Objectives: Nucleotide oligomerization domain 2 (NOD2) and myeloid differentiation protein 2 (MD-2) have crucial roles in the innate immune system.
NOD2 is a member of the NOD-like receptor (NLR) family of pattern recognition receptors (PRRs), while MD-2 is a coreceptor for Toll-like receptor 4 (TLR4), which comprises another group of PRRs.
Genetic variations in the NOD2 and MD-2 genes may be susceptibility factors to viral pathogens including hepatitis B virus (HBV).
We investigated whether polymorphisms at NOD2 (rs2066845 and rs2066844) or at MD-2 (rs6472812 and rs11466004) were associated with susceptibility to HBV infection and advancement to related liver complications in a Saudi Arabian population.
Methods: A total of 786 HBV-infected patients and 600 healthy uninfected controls were analyzed in the present study.
HBV-infected patients were categorized into three groups based on the clinical stage of the infection: inactive HBV carriers, active HBV carriers, and patients with liver cirrhosis + hepatocellular carcinoma (HCC).
Results: All four SNPs were significantly associated with susceptibility to HBV infection although none of the SNPs tested in NOD2 and MD-2 were significantly associated with persistence of HBV infection.
We found that HBV-infected patients that were homozygous CC for rs2066845 in the NOD2 gene were at a significantly increased risk of progression to HBV-related liver complications (Odds Ratio = 7.443 and P = 0.044).
Furthermore, haplotype analysis found that the rs2066844-rs2066845 C-G and T-G haplotypes at the NOD2 gene and four rs6472812- rs11466004 haplotypes (G-C, G-T, A-C, and A-T) at the MD-2 gene were significantly associated with HBV infection in the affected cohort compared to those found in our control group.
Conclusion: We found that the single nucleotide polymorphisms rs2066844 and rs2066845 at NOD2 and rs6472812 and rs11466004 at MD-2 were associated with susceptibility to HBV infection in a Saudi population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Anazi, Mashael R.& Nazir, Nyla& Abdu, Ayman A.& Sanai, Faisal M.& al-Kahtani, Sad Ali& al-Arifi, S. M.…[et al.]. 2019. Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection. Saudi Journal of Biological Sciences،Vol. 26, no. 2, pp.270-280.
https://search.emarefa.net/detail/BIM-892327
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Anazi, Mashael R.…[et al.]. Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection. Saudi Journal of Biological Sciences Vol. 26, no. 2 (Feb. 2019), pp.270-280.
https://search.emarefa.net/detail/BIM-892327
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Anazi, Mashael R.& Nazir, Nyla& Abdu, Ayman A.& Sanai, Faisal M.& al-Kahtani, Sad Ali& al-Arifi, S. M.…[et al.]. Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 2, pp.270-280.
https://search.emarefa.net/detail/BIM-892327
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in .
رقم السجل
BIM-892327
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر