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Differentiation and homing of bone marrow-derived mesenchymal stem cells in the liver schistosoma infected mice
المؤلفون المشاركون
Salamah, Marwah A.
Abd al-Hamid, Inas F.
Salih, Amirah A.
Fawzi, Iman M.
Salih, Ayman A.
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 49، العدد 2 (31 أغسطس/آب 2019)، ص ص. 249-256، 8ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2019-08-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Schistosomiasis is an endemic parasitic infective disease that remains widespread in several countries.
This work aimed to evaluate the curative influence of bone marrow derived mesenchymal stem cells (BM-MSC) engraftment in liver of schistosomiasis chronic infected mice.
30 Swiss albino mice divided into 3 groups of 10 mice each.
G1: normal healthy group, G2: infected with Schistosoma mansoni cercariae subcutaneously and G3: infected and transplanted with BM-MSC on their 8th week post infection by intravenous injection.
All mice were sacrificed 4 weeks post-transplantation.
Serum was collected for assessment of albumin, ALT & AST levels.
Engraftment of BM-MSC was assessed by labeling with PKH26.
Histopathological and ultrastructural studies were carried out.
Expression of capase-3 & IL-1as a marker of apoptosis and inflammation respectively were measured by quantitative RT-PCR.
Homing of transplanted BM-MSC within the injured liver was confirmed by fluorescent microscopic examination.
MSC labeled with PKH26 were recovered in liver.
Histopathological and electron microscopic examinations of liver showed differentiation of transplanted BM-MSC into hepatocyte-like cells.
Liver function was improved confirmed by elevation of serum albumin and decrease of ALT & AST in G3.
Real-time PCR revealed that BM-MSC inhibited capase-3 and suppressinterleukin-1 mRNA expression in damaged liver tissues.
MSC-treated group had the least apoptosis cells and inflammatory cells.
Transplantation of BM-MSCs has therapeutic anti-apoptotic anti-inflammatory mechanisms effect in chronic liver disease
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salih, Amirah A.& Salih, Ayman A.& Abd al-Hamid, Inas F.& Fawzi, Iman M.& Salamah, Marwah A.. 2019. Differentiation and homing of bone marrow-derived mesenchymal stem cells in the liver schistosoma infected mice. Journal of the Egyptian Society of Parasitology،Vol. 49, no. 2, pp.249-256.
https://search.emarefa.net/detail/BIM-893248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salih, Amirah A.…[et al.]. Differentiation and homing of bone marrow-derived mesenchymal stem cells in the liver schistosoma infected mice. Journal of the Egyptian Society of Parasitology Vol. 49, no. 2 (Aug. 2019), pp.249-256.
https://search.emarefa.net/detail/BIM-893248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salih, Amirah A.& Salih, Ayman A.& Abd al-Hamid, Inas F.& Fawzi, Iman M.& Salamah, Marwah A.. Differentiation and homing of bone marrow-derived mesenchymal stem cells in the liver schistosoma infected mice. Journal of the Egyptian Society of Parasitology. 2019. Vol. 49, no. 2, pp.249-256.
https://search.emarefa.net/detail/BIM-893248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendix : p. 255-256
رقم السجل
BIM-893248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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