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Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population
المؤلفون المشاركون
Hassab, Aminah H.
Dayf, Ahmad H.
al-Nili, Daliya A.
Tawadros, Ireny M.
Fayyd, Amirah I.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 20، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 1-9، 9ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2019-01-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background: Hypovitaminos is D is one of the hazardous factors for multiple sclerosis (MS) and can be attested by expanding clinical studies.
We aimed to study vitamin D receptor (VDR) gene polymorphisms: Fokl, Bsml, Apal, Taql, and Tru9l genotype; frequency; haplotype structure; and linkage disequilibrium (LD) in MS Egyptian patients.
The study was conducted on 50 MS patients and 50 healthy controls of matching age and sex.
Alleles and genotype variants of VDR gene SNPs were analyzed by PCR using the restriction fragment length polymorphism (RFLP).
Haplotype and linkage disequilibrium analysis based on the five genetic loci was studied on the detected genotypes.
Results: Frequency of Fokl genotype (Ff+ff) was significantly higher in healthy controls (50%) compared to MS (28%) (P = 0.03), and T allele was significantly associated with the control group (OR = 0.42, Cl = 026-0.85, P=0.015).
Frequency of Apal genotype (Aa+aa) was significantly higher in MS (60%) (P=0.002), and "a" allele was significantly associated with MS cases (OR = 2.47, Cl = 1.25-4.88, P = 0.008).
Taql allelic distribution showed significant association of Y allele with control group (OR = 055, Cl = 031-0.98, P = 0.04).
Statistically significant LD was detected between Bsml and Apal in controls and MS {D =0.89 and P < 0.001, and D' = 052 and P < 0.001), respectively.
Odd ratios of “fAt" and "BAt" were 02 (95% Q = 0.06-0.66) and 0.43 (95% Cl = 0.19-0.97), respectively, suggesting that MS risk was 5 times and 23 times lesser, respectively, for haplotype carriers compared to non-carriers.
Conclusion: The study findings suggest that VDR gene variants "f," "A," and Y alleles as well as VDR gene hapbtypes “BAt" and “fAt" may have a protective effect against MS disease in Egyptian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassab, Aminah H.& Dayf, Ahmad H.& al-Nili, Daliya A.& Tawadros, Ireny M.& Fayyd, Amirah I.. 2019. Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population. The Egyptian Journal of Medical Human Genetics،Vol. 20, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-893603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassab, Aminah H.…[et al.]. Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population. The Egyptian Journal of Medical Human Genetics Vol. 20, no. 1 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-893603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassab, Aminah H.& Dayf, Ahmad H.& al-Nili, Daliya A.& Tawadros, Ireny M.& Fayyd, Amirah I.. Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population. The Egyptian Journal of Medical Human Genetics. 2019. Vol. 20, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-893603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-893603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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