Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis : a single-center experience

المؤلفون المشاركون

al-Mayuf, Sulayman Muhammad
al-Hamzi, Hanan A.
al-Shaykh, Salman A.
al-Shaykh, Haifa A.
al-Shumar, Ahmad A.
al-Humaydan, Hind A.
al-Dalaan, Abd Allah N.
al-Salih, Salman S.

المصدر

Saudi Journal of Kidney Diseases and Transplantation

العدد

المجلد 30، العدد 4 (31 أغسطس/آب 2019)، ص ص. 775-780، 6ص.

الناشر

المركز السعودي لزراعة الأعضاء

تاريخ النشر

2019-08-31

دولة النشر

السعودية

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Therapeutic plasma exchanges (TPE) is considered as one of the treatment modalities that is used in systemic autoimmune diseases.

This study aimed to describe the early and late effect of TPE in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) presented with acute kidney injury (AKI).

Retrospective study comprised patients with SLE and AAV with AKI seen between January 2000 and June 2014 at King Faisal Specialist Hospital and Research Center in Riyadh.

All patients underwent TPE.

Retrospectively, all patients were assessed for early and late renal outcome at 12- month and 24-month intervals.

Renal outcome was assessed according to serum creatinine level, glomerular filtration rate, active urine sediment, and proteinuria.

P <0.05 was considered significant.

A total of 68 patients were included, 58 patients (51 females) had SLE and 10 patients (7 females) had AAV completed TPE.

All patients had active disease and had AKI.

At the first 12 months, 18 patients (17 SLE and 1 AAV) showed complete response and 14 patients had partial response while 22 patients did not show therapeutic benefit.

The nonresponders (22 patients) entered the late assessment interval (24 months) without any therapeutic response.

Statistically, there was no significant difference between the patient’s response to TPE at the first and second assessment intervals and the baseline serum creatinine level.

TPE might be an alternative rescue treatment in lupus nephritis with AKI.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

al-Hamzi, Hanan A.& al-Mayuf, Sulayman Muhammad& al-Shaykh, Salman A.& al-Shaykh, Haifa A.& al-Shumar, Ahmad A.& al-Humaydan, Hind A.…[et al.]. 2019. Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 4, pp.775-780.
https://search.emarefa.net/detail/BIM-893625

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

al-Hamzi, Hanan A.…[et al.]. Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 4 (Jul. / Aug. 2019), pp.775-780.
https://search.emarefa.net/detail/BIM-893625

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

al-Hamzi, Hanan A.& al-Mayuf, Sulayman Muhammad& al-Shaykh, Salman A.& al-Shaykh, Haifa A.& al-Shumar, Ahmad A.& al-Humaydan, Hind A.…[et al.]. Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 4, pp.775-780.
https://search.emarefa.net/detail/BIM-893625

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 779-780

رقم السجل

BIM-893625