Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis : a university hospital experience
المؤلفون المشاركون
Hamzah, Wail M.
Shakir, Amr M.
Wadie, Mary
Fayid, Ahmad Hasan
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 4 (31 أغسطس/آب 2019)، ص ص. 803-811، 9ص.
الناشر
تاريخ النشر
2019-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Rheumatoid arthritis (RA) is accompanied by a variety of nephropathies.
It is often difficult to distinguish between disease-associated and drug-associated renal diseases.
Three hundred and seventy-six RA patients with renal involvement were included in our study; they were subjected to full history and clinical examination, kidney function, 24-h urinary protein, and kidney biopsy.
All our patients were on methotrexate, low dose steroids, and nonsteroidal antiinflammatory drugs, in addition to the previous medications.
About 79.3%, 20.7%, 6.9%, and 5.9% of our patients were on leflunomide, hydroxychloroquine, etanercept, and infliximab, respectively.
Renal presentation was in the form of nephrotic syndrome (33.5%), persistent subnephrotic proteinuria (12.2%), persistent proteinuria and recurrent hematuria (13.3%), acute nephritis (23.9), recurrent hematuria (7.4%), and creatinine >1.5 mg/dL (10.6%).
Renal biopsies were glomerular amyloidosis (28.1%), mesangioproliferative (19.1%), membranous (6.1%), crescent (16.8%), focal segmental glomerulosclerosis (18.6%), and minimal changes (11.7%).
There was a statistically significant difference in the incidence of membranous nephritis between patients who took leflunomide, and hydroxychloroquine and those did not.
Etanercept in our study seems not to be related to any form of renal involvement, while infliximab is related to focal segmental sclerosis and amyloidosis of tubulointerstitial type.
Kidney involvement in RA is not a rare complication.
Any type of histopathological changes can be present, with amyloidosis on top of the list.
Hydroxychloroquine and leflunomide are accused in membranous nephropathy.
Infliximab is associated with focal segmental sclerosis and amyloidosis of tubulointerstial type, and etanercept appear to be safe as regards kidney affection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fayid, Ahmad Hasan& Shakir, Amr M.& Hamzah, Wail M.& Wadie, Mary. 2019. Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis : a university hospital experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 4, pp.803-811.
https://search.emarefa.net/detail/BIM-893636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fayid, Ahmad Hasan…[et al.]. Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis : a university hospital experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 4 (Jul. / Aug. 2019), pp.803-811.
https://search.emarefa.net/detail/BIM-893636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fayid, Ahmad Hasan& Shakir, Amr M.& Hamzah, Wail M.& Wadie, Mary. Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis : a university hospital experience. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 4, pp.803-811.
https://search.emarefa.net/detail/BIM-893636
نوع البيانات
مقالات
لغة النص
الإنجليزية
رقم السجل
BIM-893636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر