Association study of APOE gene polymorphisms with diabetes and the main ardiometabolic risk factors, in the Algerian population
المؤلفون المشاركون
Bu Linawar, Husam
Bin Shakur, Suniya Madyani
Jalluli, Hajir Wuhaybi
Hatraf, Sarah Aishah Larjam
Huti, Layla
Majawi, Iman Hammani
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 20، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 1-8، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2019-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Metabolic syndrome (MetS) represents a combination of at least three primary metabolic abnormalities among which obesity, hyperglycemia, dyslipidemia, and high blood pressure (HBP); once combined, they increase the cardiovascular risk significantly.
APOE gene is considered as a genetic risk factor for cardiovascular diseases, and it has been linked to Me6 or related disorders in several populations.
Our study aimed to analyze, for the first time, the association of three APOE gene polymorphisms with MetS risk and its components in a general Algerian population sample, and to highlight the potential influence of these polymorphisms on individual susceptibility to MetS, diabetes, high blood pressure, and obesity, which has never been studied before in the Algerian population.
Results: The rs439401 showed a significant association with hypertension.
The T allele confers a high risk of hypertension with an odds ratio (OR) of 1.46 (95% Cl [1.12-1.9], p= 0.006).
The rs4420638 polymorphism was significantly associated with obesity in the general population.
The G allele provides protection against obesity; the resulting OR is 0.48 (95% Cl [0.29-0.81], p= 0.004).
Conclusions: Although APOE variants were not associated with the risk of MetS, the APOE polymorphism alleles were associated with some of the metabolic parameters in Algerian subjects.
The relation of APOE rs439401 alleles with high blood pressure seems indicative of a state of stress of the population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bu Linawar, Husam& Bin Shakur, Suniya Madyani& Jalluli, Hajir Wuhaybi& Hatraf, Sarah Aishah Larjam& Huti, Layla& Majawi, Iman Hammani. 2019. Association study of APOE gene polymorphisms with diabetes and the main ardiometabolic risk factors, in the Algerian population. The Egyptian Journal of Medical Human Genetics،Vol. 20, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-893667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bu Linawar, Husam…[et al.]. Association study of APOE gene polymorphisms with diabetes and the main ardiometabolic risk factors, in the Algerian population. The Egyptian Journal of Medical Human Genetics Vol. 20, no. 1 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-893667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bu Linawar, Husam& Bin Shakur, Suniya Madyani& Jalluli, Hajir Wuhaybi& Hatraf, Sarah Aishah Larjam& Huti, Layla& Majawi, Iman Hammani. Association study of APOE gene polymorphisms with diabetes and the main ardiometabolic risk factors, in the Algerian population. The Egyptian Journal of Medical Human Genetics. 2019. Vol. 20, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-893667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-893667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر