Toxoplasmosis and abortion : pro-and anti-inflammatory cytokines gene expression of the host immune cells
المؤلفون المشاركون
Abd al-Al, Amani A.
Abd al-Aziz, Inas Z.
al-Shirbini, Muna Said
al-Shirbini, Walid Sayyid
Atiyyah, Samar Sayyid
Nasr, Ghadah M.
Badr, Muhammad S.
Salamah, Muhammad Sayyid
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 20، العدد 1 (31 يناير/كانون الثاني 2019)، ص ص. 1-10، 10ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2019-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background: Toxoplasmosis during pregnancy is known for inducing variable serious outcomes.
In many previous studies, pregnancy was evaluated as a single event while in reality; it has different distinct immunological stages depending on gestational time and possible external factors as infectious agents.
A state of immunological balance as well as a state of maternal-fetal tolerance should be established; otherwise, atypical unwelcomed outcomes might occur as a result of such infection Aim: This work aimed to study the gene expression profile of some pro- and anti-inflammatory cytokines in Toxoplasma seropositive cases Results: All studied cytokines were significantly upregulated in group I, with a remarkable bias towards IFN-y, denoting a predominant inflammatory state in group I.
In group II; tested cytokines were approximately in a balanced state with a little shift towards anti-inflammatory cytokines (IL-10 and TGF-0).
A significant positive correlation was detected between pro-inflammatory together (p =0.002, r = 0.96) and between anti-inflammatory cytokines together (p =0.0008, r= 0.99) in group llf indicating the harmonized and synchronized expression of both pro- and anti-inflammatory cytokines.
In group III, IL-10 was relatively higher with negative correlation with IFN-y (p = 0.006, r = 0.93), indicating the possible role of I LI 0 in saving some of the pregnancies’ outcomes in group III.
Conclusion: The present study suggests a potential role of these cytokines in the upcoming prognostic or/and therapeutic concerns of toxoplasmosis among pregnant women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Shirbini, Muna Said& Abd al-Al, Amani A.& al-Shirbini, Walid Sayyid& Atiyyah, Samar Sayyid& Abd al-Aziz, Inas Z.& Salamah, Muhammad Sayyid…[et al.]. 2019. Toxoplasmosis and abortion : pro-and anti-inflammatory cytokines gene expression of the host immune cells. The Egyptian Journal of Medical Human Genetics،Vol. 20, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-893676
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salamah, Muhammad Sayyid…[et al.]. Toxoplasmosis and abortion : pro-and anti-inflammatory cytokines gene expression of the host immune cells. The Egyptian Journal of Medical Human Genetics Vol. 20, no. 1 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-893676
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Shirbini, Muna Said& Abd al-Al, Amani A.& al-Shirbini, Walid Sayyid& Atiyyah, Samar Sayyid& Abd al-Aziz, Inas Z.& Salamah, Muhammad Sayyid…[et al.]. Toxoplasmosis and abortion : pro-and anti-inflammatory cytokines gene expression of the host immune cells. The Egyptian Journal of Medical Human Genetics. 2019. Vol. 20, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-893676
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-10
رقم السجل
BIM-893676
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر